Comparison of major histocompatibility complex‐B variability in Sri Lankan indigenous chickens with five global chicken populations using MHC‐B SNP panel. (14th September 2021)

• Record Type: Journal Article
• Authors: Manjula, P.; Fulton, J. E.; Seo, D.; Lee, J. H.
• Is Part Of: Animal genetics. Volume 52:Number 6(2021)
• Page Start: 824
• Page End: 833
• Publication Date: 2021-09-14
• Subjects: crossbreed -- disease resistance -- haplotype diversity -- major histocompatibility complex‐B -- Sri Lankan indigenous chicken; Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.13137
• Languages: English
• ISSNs: 0268-9146

Abstract

Summary: In the present study, we investigated the major histocompatibility complex (MHC)‐ B haplotypes diversity of Sri Lankan indigenous chickens from three different geographical sites consisting of highly mixed populations using 90 SNPs in the MHC‐ B region. A total of 48 haplotypes were identified. Those included 37 novel haplotypes and 11 previously identified 'standard' haplotypes. The MHC‐linked marker, LEI0258, had 23 alleles showing less diversity than defined by MHC‐ B SNP haplotypes. Among those identified haplotypes, five standard haplotypes—BSNP‐O02, BSNP‐M01, BSNP‐A04, BSNP‐K03, BSNP‐T04—were most commonly observed, suggesting past introgression of imported breeds. Comparison of the MHC‐ B haplotypes of Sri Lankan and four other global populations with previously defined haplotypes indicated the sharing of 23 standard haplotypes with common origins. Novel haplotypes are population‐specific and not shared among the geographical boundaries. Backyard indigenous chickens are unselected, highly crossbred, and generally thrive under dynamic environmental conditions. Hence free‐range production systems may be responsible for maintaining high diversity in the MHC‐ B region with novel haplotypes.