Psoriasis associated with idiopathic CD4+ T‐cell lymphopenia: a regulatory T‐cell defect?. (1st July 2014)

• Record Type: Journal Article
• Authors: Baroudjian, B.; Viguier, M.; Battistella, M.; Beneton, N.; Pagès, C.; Gener, G.; Bégon, E.; Bachelez, H.
• Is Part Of: British journal of dermatology. Volume 171:Number 1(2014:Jul.)
• Page Start: 186
• Page End: 189
• Publication Date: 2014-07-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12922
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Idiopathic CD4 + lymphocytopenia (ICL) is a rare immunodeficiency syndrome of unknown origin for which the increased risks of opportunistic infections and of malignancies have been well established; however, skin dysimmune diseases, including psoriasis, have been scarcely reported up to now. We report herein the severe course of psoriasis in four patients with ICL, and show evidence for a defect in the skin recruitment of regulatory CD4 + FoxP3 + T cells. These data raise the apparent paradigm of the occurrence of a severe immunomediated disease together with a profound T‐cell defect, a model that might also apply to other immune deficiencies associated with psoriasis.