A Systematic Review of COVID-19 Vaccine Antibody Responses in People With HIV. (8th November 2022)

• Record Type: Journal Article
• Authors: Chun, Helen M; Milligan, Kyle; Agyemang, Elfriede; Ford, Nathan; Rangaraj, Ajay; Desai, Shalini; Wilder-Smith, Annelies; Vitoria, Marco; Zulu, Isaac
• Is Part Of: Open forum infectious diseases. Volume 9:Number 11(2022)
• Publication Date: 2022-11-08
• Subjects: COVID-19 vaccines -- people with HIV -- SARS-CoV-2 antibody -- seroconversion; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac579
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: HIV infection is a significant independent risk factor for severe coronavirus disease 2019 (COVID-19) disease and death. We summarize COVID-19 vaccine responses in people with HIV (PWH). A systematic literature review of studies from January 1, 2020, to March 31, 2022, of COVID-19 vaccine immunogenicity in PWH from multiple databases was performed. Twenty-eight studies from 12 countries were reviewed. While 22 (73%) studies reported high COVID-19 vaccine seroconversion rates in PWH, PWH with lower baseline CD4 counts, CD4/CD8 ratios, or higher baseline viral loads had lower seroconversion rates and immunologic titers. Data on vaccine-induced seroconversion in PWH are reassuring, but more research is needed to evaluate the durability of COVID-19 vaccine responses in PWH.