Prognostic value of cardiac magnetic resonance early after ST-segment elevation myocardial infarction in older patients. (27th November 2022)

• Record Type: Journal Article
• Authors: Gabaldón-Pérez, Ana; Marcos-Garcés, Víctor; Gavara, José; López-Lereu, María P; Monmeneu, José V; Pérez, Nerea; Ríos-Navarro, César; de Dios, Elena; Merenciano-González, Héctor; Cànoves, Joaquim; Racugno, Paolo; Bonanad, Clara; Minana, Gema; Núnez, Julio; Moratal, David; Chorro, Francisco J; Valente, Filipa; Lorenzatti, Daniel; Ortiz-Pérez, Jose T; Rodríguez-Palomares, Jose F; Bodí, Vicente
• Is Part Of: Age and ageing. Volume 51:Number 11(2022)
• Publication Date: 2022-11-27
• Subjects: myocardial infarction -- older patients -- cardiac magnetic resonance -- risk -- prognosis -- older people; Aging -- Periodicals; Geriatrics -- Periodicals; 618.97
• DOI: 10.1093/ageing/afac248
• Languages: English
• ISSNs: 0002-0729

Abstract

Abstract: Background: older patients with ST-segment elevation myocardial infarction (STEMI) represent a very high-risk population. Data on the prognostic value of cardiac magnetic resonance (CMR) in this scenario are scarce. Methods: the registry comprised 247 STEMI patients over 70 years of age treated with percutaneous intervention and included in a multicenter registry. Baseline characteristics, echocardiographic parameters and CMR-derived left ventricular ejection fraction (LVEF, %), infarct size (% of left ventricular mass) and microvascular obstruction (MVO, number of segments) were prospectively collected. The additional prognostic power of CMR was assessed using adjusted C-statistic, net reclassification index (NRI) and integrated discrimination improvement index (IDI). Results: during a 4.8-year mean follow-up, the number of first major adverse cardiac events (MACE) was 66 (26.7%): 27 all-cause deaths and 39 re-admissions for acute heart failure. Predictors of MACE were GRACE score (HR 1.03 [1.02–1.04], P < 0.001), CMR–LVEF (HR 0.97 [0.95–0.99] per percent increase, P = 0.006) and MVO (HR 1.24 [1.09–1.4] per segment, P = 0.001). Adding CMR data significantly improved MACE prediction compared to the model with baseline and echocardiographic characteristics (C-statistic 0.759 [0.694–0.824] vs. 0.685 [0.613–0.756], NRI = 0.6, IDI = 0.08, P < 0.001). The best cut-offs for independent variables were GRACE score > 155, LVEF < 40% and MVO ≥ 2 segments. A simple score (0, 1, 2, 3) based on the number of altered factors accurately predicted the MACE per 100 person-years: 0.78, 5.53, 11.51 and 78.79, respectively ( P < 0.001). Conclusions: CMR data contribute valuable prognostic information in older patients submitted to undergo CMR soon after STEMI. The Older-STEMI–CMR score should be externally validated. Graphical Abstract: