Corrigendum to "PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes" [Environ. Pollut. 305 (2022) 119340]. (15th January 2023)

• Record Type: Journal Article
• Authors: Davidsen, Nichlas; Ramhøj, Louise; Lykkebo, Claus Asger; Kugathas, Indusha; Poulsen, Rikke; Rosenmai, Anna Kjerstine; Evrard, Bertrand; Darde, Thomas A.; Axelstad, Marta; Bahl, Martin Iain; Hansen, Martin; Chalmel, Frederic; Licht, Tine Rask; Svingen, Terje
• Is Part Of: Environmental pollution. Volume 317(2023)
• Publication Date: 2023-01-15
• Subjects: PFOS -- Thyroid hormone -- Transcriptomics -- Vancomycin -- Endocrine disrupting chemicals -- Perfluorooctane sulfonate -- PFAS -- Perfluoroalkyl -- Thyroid -- HPT-Axis; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.120709
• Languages: English
• ISSNs: 0269-7491

Abstract

Highlights: PFOS exposure decrease T4, T3, rT3 and T1Ac in adult male rats. PFOS reduces thyroid hormone concentrations without activating the HPT-axis. PFOS alters gene expression in hypothalamus, pituitary, thyroid and liver. PFOS dysregulates axon function and vesicle transport genes in hypothalamus. Compromised gut microbiome had no significant effect on PFOS-induced DEGs.