Reversible tissue sticker inspired by chemistry in plant-pathogen relationship. (1st January 2023)

• Record Type: Journal Article
• Authors: Lee, Jeehee; Park, Eunsook; Lee, Kyueui; Shin, Mikyung; Lee, Soohyeon; Moreno-Villaécija, Miguel Ángel; Lee, Haeshin
• Is Part Of: Acta biomaterialia. Volume 155(2023)
• Page Start: 247
• Page End: 257
• Publication Date: 2023-01-01
• Subjects: Polysaccharide -- Phenol -- O-acetyl -- Bio-inspired -- Hydrogen bonding; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2022.09.075
• Languages: English
• ISSNs: 1742-7061

Abstract

Abstract: Plants release phenolic molecules to protect against invading pathogens. In plant-microorganism relationships, phenolics bind to surface oligosaccharides, inactivating microorganism activities. Inspired by phenol-saccharide interactions in plant defense systems, we designed an adhesive sealant. By screening 16 different saccharides, the O-acetyl group, rich in glucomannan (GM), exhibited rapid, robust binding with the galloyl moiety of a model phenolic molecule, tannic acid (TA). Furthermore, the interaction showed both pH and temperature (upper critical solution temperature) sensitivities. Utilizing O-acetyl-galloyl interactions, materials of all dimensions from beads (0D) to strings (1D), films (2D), and objects (3D) could be prepared, as a suitable platform for printing techniques. GMTA films are elastic, adhesive, water-resistant, and effectively sealed perforations, as demonstrated by (1) a lung incision followed by an air inflation model and (2) a thoracic diaphragm model. Statement of significance: In nature, phenolic molecules are 'nearly always' physically bound with polysaccharides, indicating that the phenolics widen the functions of polysaccharides. An example includes that phenolic-polysaccharide interactions are key defense mechanisms against microbial infection in plants whereas polysaccharide alone functions poorly. Despite the ubiquitous biochemistry of polysaccharide-phenolic interactions, efforts on understanding binding chemistry focusing on phenol/polysaccharide interactions is little. This study is important because we found for the first time that O-acetyl group is the moiety in polysaccharides to which phenolic cis-diol and/or cis-triol is spontaneously bound. The phenol-polysaccharide interaction is non-covalent yet robust, kinetically fast, and reversible. Inspired by the interaction chemistry, a simple mixture of phenolic molecules and O-acetyl group containing polysaccharides such as glucomannan opens a promising fabrication strategy toward functional polysaccharide-based material. Graphical abstract: Image, graphical abstract