Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges. (January 2023)

• Record Type: Journal Article
• Authors: Banerjee, Srishti; Ray, Sandipan
• Is Part Of: Progress in neurobiology. Volume 220(2023)
• Publication Date: 2023-01
• Subjects: 5-HT2C 5-hydroxytryptamine, 5-ht -- ACTH adrenocorticotropic hormone -- AKT protein kinase b (PKB) -- AMPK amp-activated protein kinase -- ATM ataxia telangiectasia mutated -- BCR breakpoint cluster region protein -- BMAL1 brain and muscle arnt-like 1 -- cAMP cyclic adenosine monophosphate -- CAND2 cullin-associated and neddylation-dissociated 2 (putative) -- CircaDB circadian expression profiles database -- CK casein kinase -- CLOCK circadian locomotor output cycle kaput -- CR calorie restriction -- CREB camp response element-binding protein -- CRSWDs circadian rhythm sleep-wake disorders -- CRY cryptochrome -- Castor1/Gatsl3 gats protein-like 3 -- GABAARs γ-aminobutyric acid type a receptors -- GSK glycogen synthase kinase 3 -- HPA hypothalamic-pituitary axis -- IF intermittent fasting -- IIS insulin/IGF (insulin-like growth factor)-like signaling -- Lkb1/Stk11 serine/threonine kinase 11 -- MAPK mitogen-activated protein kinase -- MT1/MTNR1A melatonin receptor type 1a -- mTOR mechanistic target of rapamycin -- mTORC1 mechanistic target of rapamycin complex 1 -- N24SWD non-24-h sleep-wake rhythm disorder -- NAD nicotinamide adenine dinucleotide -- Ndufs nadh dehydrogenase (ubiquinone) fe-s protein -- Ndufv nadh dehydrogenase (ubiquinone) flavoprotein -- NR1D1/Rev-Erbs nuclear receptor subfamily 1 group d member 1 -- Oct1/Slc22a1 organic cation transporter-1/solute carrier family 22-member 1 -- PER period -- ROR retinoic acid orphan receptors -- SCN suprachiasmatic nucleus -- SIRT1/6 sirtuin1/6 -- Slc2a2 solute carrier family 2 (facilitated glucose transporter) member 2 -- TERT telomerase reverse transcriptase -- TRF time-restricted feeding -- VDR vitamin D receptor; Circadian rhythm -- Aging -- Sleep disorders -- Chronomedicine -- Melatonin -- Metformin; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2022.102387
• Languages: English
• ISSNs: 0301-0082

Abstract

Abstract: Aging causes progressive deterioration of daily rhythms in behavioral and metabolic processes and disruption in the regular sleep-wake cycle. Circadian disruption is directly related to diverse age-induced health abnormalities. Rising evidence from various organisms shows that core clock gene mutations cause premature aging, reduced lifespan, and sleeping irregularities. Improving the clock functions and correcting its disruption by pharmacological interventions or time-regulated feeding patterns could be a novel avenue for effective clinical management of aging and sleep disorders. To this end, many drugs for sleep disorders and anti-aging compounds interact with the core clock machinery and alter the circadian output. Evaluation of dosing time-dependency and circadian regulation of drug metabolism for therapeutic improvement of the existing drugs is another fundamental facet of chronomedicine. Multiple studies have demonstrated dose-dependent manipulation of the circadian period and phase-shifting by pharmacologically active compounds. The chronobiology research field is gradually moving towards the development of novel therapeutic strategies based on targeting the molecular clock or dosing time-oriented medications. However, such translational research ventures would require more experimental evidence from studies on humans. This review discusses the impact of circadian rhythms on aging and sleep, emphasizing the potentiality of circadian medicine in aging attenuation and sleep disorders. Highlights: Circadian disruption is often observed in aging and sleep disorders. Boosting the clock functions could help attenuate aging and sleep disorders. Many anti-aging compounds interact with the circadian clock components. Molecular targets of metformin and melatonin exhibit robust 24-h rhythms. The dosing time of medication scan influence their therapeutic efficacy.