A comparative monitoring of maternal and cord serum polychlorinated biphenyls levels from Iranian pregnant women between industrial and urban areas. (15th January 2023)

• Record Type: Journal Article
• Authors: Khalili Doroodzani, Atefeh; Dobaradaran, Sina; Rahmani, Elham; Nabipour, Iraj; Malekizadeh, Hasan; Raeisi, Alireza; Farhadi, Akram; Mahmudpour, Mehdi; Afrashteh, Sima; Saeedi, Reza
• Is Part Of: Environmental pollution. Volume 317(2023)
• Publication Date: 2023-01-15
• Subjects: Fetal growth -- Industrial area -- Maternal serum -- Polychlorinated biphenyls -- Umbilical cord serum -- Urban area; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.120781
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The aim of this study was to compare maternal and fetal exposure to PCBs in pregnant women from a petrochemical and gas area (PGA) and an urban area (UA), by the analyses of serum samples from mother (MS) and cord (CS). After liquid-liquid extracting, samples were analyzed for 12 PCBs congeners by gas chromatography mass spectrometer. Adjusted multiple linear regression models showed the mean levels (μg/L) of total PCBs in the MS and CS samples from the PGA (1.70 ± 0.81 and 1.19 ± 0.43) were significantly higher than those from UA (1.64 ± 0.75 and 1.07 ± 0.38). PCB 44 was predominant in both MS and CS serum samples, and in both PGA (0.80 ± 0.70 and 0.76 ± 0.67) and UA (0.79 ± 0.39 and 0.67 ± 0.34). A negative correlation was found for PCB 52 as one-unit increase in the cord serum levels was associated with 0.024 g decrease in newborn weight. Similarly, one-unit increase in the maternal serum PCB 18 concentrations were associated with 0.09 and 0.086 cm decrease in newborn height and head circumference. The serum levels of PCB 18 and 52 in the mothers who consumed meat and milk at least 1 meal/week were higher than these who consumed meat and milk never or less than 1 meal/month. The findings in this study indicated that higher maternal exposure to PCBs, as result of living in an industrialized area, leads to higher PCBs accumulation in cord blood, which consequently passes to the developing fetus. These events may cause harmful effects on both them in-utero and afterbirth growth and development. Graphical abstract: Image 1 Highlights: ΣPCBs in maternal and cord serums from industrial area was higher than urban area. PCB 18, 44 and 52 were detected in maternal and cord serum samples. PCB 44 was predominant compound in maternal and cord serum samples. A negative association was observed for cord serum PCB 52 and birth weight. Maternal serum PCB18 was inversely related with birth height and head circumference.