MiR-3150b inhibits hepatocellular carcinoma cell proliferation, migration and invasion by targeting GOLPH3. (March 2020)

• Record Type: Journal Article
• Authors: Zhang, Yi; Wang, Jianjun; Su, Hongling
• Is Part Of: Journal of investigative medicine. Volume 68:Number 3(2020)
• Page Start: 770
• Page End: 775
• Publication Date: 2020-03
• Subjects: Golgi phosphoprotein 3 -- hepatocellular carcinoma -- migration -- miR-3150b -- proliferation; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2019-001181
• Languages: English
• ISSNs: 1081-5589

Abstract

Background: In this study, we aimed to explore the potential involvement of miR-3150b in hepatocellular carcinoma (HCC) carcinogenesis. Methods: The expression of miR-3150b and Golgi phosphoprotein 3 (GOLPH3) was determined in HCC cell lines. Cell proliferation, migration and invasion were estimated by Cell Counting Kit-8, wound healing and Transwell assays. The association between miR-3150b and GOLPH3 was verified by luciferase assay. Results: MiR-3150b was downregulated, while GOLPH3 was remarkably upregulated in HCC cells. Furthermore, miR-3150b inhibited HCC cell proliferation, migration and invasion. MiR-3150b directly targeted and negatively regulated GOLPH3. Conclusion: MiR-3150b suppressed HCC cell proliferation, invasion and migration by targeting GOLPH3.