Checkpoint Inhibitors in Head and Neck Cancer: Current Knowledge and Perspectives. (October 2018)

• Record Type: Journal Article
• Authors: Samra, Bachar; Tam, Eric; Baseri, Babak; Shapira, Iuliana
• Is Part Of: Journal of investigative medicine. Volume 66:Number 7(2018)
• Page Start: 1023
• Page End: 1030
• Publication Date: 2018-10
• Subjects: cancer -- immunotherapy -- adoptive -- antibodies -- monoclonal -- carcinoma -- squamous cell -- neoplasms; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2018-000743
• Languages: English
• ISSNs: 1081-5589

Abstract

The emergence of immunotherapy has provided significant clinical improvements in the treatment of metastatic solid tumors. Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) has dismal prognosis with median survival ranging between 6and12 months. Our aim is to review the current knowledge on the role of the immune system and immune checkpoint inhibitors in HNSCC. We will focus on the landmark trials that led to the regulatory approvals of pembrolizumab and nivolumab, and discuss a few promising contenders in clinical development and highlight the need to identify better biomarkers other than programmed death-ligand 1 to improve patient selection and help predict response.