Are Human Adenovirus-5 and 36 Associated with Obesity in Children?. (June 2014)

• Record Type: Journal Article
• Authors: Cakmakliogullari, Elcin Kal; Sanlidag, Tamer; Ersoy, Betul; Akcali, Sinem; Var, Ahmet; Cicek, Candan
• Is Part Of: Journal of investigative medicine. Volume 62:Number 5(2014)
• Page Start: 821
• Page End: 824
• Publication Date: 2014-06
• Subjects: obesity -- children -- adenovirus serotypes -- microneutralization assay -- lipid profiles; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/JIM.0000000000000084
• Languages: English
• ISSNs: 1081-5589

Abstract

Objectives: The aims of this study were to determine the association between adenovirus-5– and adenovirus-36–specific antibodies and obesity in children and to investigate their relationship with serum lipid and leptin levels. Methods: A cross-sectional study was performed on a total of 120 children who were divided into subgroups according to body mass index percentile as obese (≥95th percentile) or nonobese (<95th percentile). The presence of adenovirus-36 and adenovirus-5–neutralizing antibodies was investigated by using the serum neutralization assay. Serum leptin levels were determined by microenzyme immonoassay; high-density lipoprotein, low-density lipoprotein, triglyceride, and cholesterol levels were measured by chemiluminescence method. Results: The presence of adenovirus-5–specific antibodies was 28.3% and 6.6% in the obese children and in non–obese children, respectively ( P = 0.02). The frequency of adenovirus-36–specific antibodies was significantly greater ( P = 0.018) in the obese children (26.6%) than in the non–obese children (10.0%). Serum leptin level of the obese group were significantly higher than that of the non–obese group ( P = 0.000). Conclusions: Our data support the association between obesity and the presence of specific antibodies to adenovirus-36 and adenovirus-5 in children. Our research has the feature of being the first national study to indicate the relationship between adenovirus-36 and human obesity as well as the first international study to indicate the relationship between adenovirus-5 and human obesity.