A study of combination unilateral subcutaneous botulinum toxin a treatment for androgenetic alopecia. (19th July 2022)

• Record Type: Journal Article
• Authors: Tian, Kai; Gao, Suyue; Jia, Zou; Xu, Wushuang; Li, Ke; Wu, Lijun
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 11(2022)
• Page Start: 5584
• Page End: 5590
• Publication Date: 2022-07-19
• Subjects: androgenic alopecia -- botulinum toxin a -- hair growth; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.15179
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Objective: To observe the efficacy of unilateral subcutaneous injection of botulinum toxin A combined with finasteride and minoxidil in the treatment of androgenic alopecia. Methods: Thirty‐seven patients with androgenic alopecia were treated with finasteride and minoxidil as standard therapy and were randomly assigned to subcutaneous injections of botulinum toxin A in one hemisphere of the head at the beginning of a 6‐month treatment. Before treatment, 3 months after treatment, and 6 months after treatment, the patient's head hair growth was photographed and evaluated. Results: After 3 and 6 months of treatment, hair density of the treated androgenic alopecia patients was higher than before treatment ( p < 0.05), and the hair density of the botulinum toxin A injection side was higher than that of the control side ( p < 0.05). After 6 months of treatment, the response rate of botulinum toxin A combined with finasteride and minoxidil was 77.5%, with no significant side effects observed. Conclusion: Finasteride and minoxidil have a significant effect on androgenic alopecia, and the effect is further increased after combined with botulinum toxin A subcutaneous injection.