Recent advances in the understanding of severe cutaneous adverse reactions. (1st November 2017)

• Record Type: Journal Article
• Authors: Adler, N.R.; Aung, A.K.; Ergen, E.N.; Trubiano, J.; Goh, M.S.Y.; Phillips, E.J.
• Is Part Of: British journal of dermatology. Volume 177:Number 5(2017)
• Page Start: 1234
• Page End: 1247
• Publication Date: 2017-11-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.15423
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Severe cutaneous adverse reactions (SCARs) encompass a heterogeneous group of delayed hypersensitivity reactions, which are most frequently caused by drugs. Our understanding of several aspects of SCAR syndromes has evolved considerably over the last decade. This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross‐reactivity data related to SCAR syndromes. Given the rarity and severity of these diseases, multidisciplinary collaboration through large international, national and/or multicentre networks to collect prospective data on patients with SCAR syndromes should be prioritized. This will further enhance a systematized framework for translating epidemiological, clinical and immunopathogenetic advances into preventive efforts and improved outcomes for patients.