3D‐Printed Centrifugal Pump Driven by Magnetic Force in Applications for Microfluidics in Biological Analysis. Issue 24 (3rd June 2022)

• Record Type: Journal Article
• Authors: Jo, Byeongwook; Morimoto, Yuya; Takeuchi, Shoji
• Other Names: Rnjak‐Kovacina Jelena guestEditor.; Choi Yu Suk guestEditor.; Lim Khoon S. guestEditor.
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 24(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-03
• Subjects: dynamic cell cultures -- lab on chips -- microfluidics -- perfusion -- tissue engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202200593
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: In recent years, microfluidic systems have been extensively utilized for biological analysis. The integration of pumps in microfluidic systems requires precise control of liquids and effort‐intensive set‐ups for multiplexed experiments. In this study, a 3D‐printed centrifugal pump driven by magnetic force is presented for microfluidics and biological analysis. The permanent magnets implemented in the centrifugal pump synchronized the rotation of the driving and operating parts. Precise control of the flow rate and a wide range and variety of flow profiles are achieved by controlling the rotational speed of the motor in the driving part. The compact size and contactless driving part allow simple set‐ups within commercially available culture dishes and tubes. It is demonstrated that the fabricated 3D‐printed centrifugal pump can induce laminar flow in a microfluidic device, perfusion culture of in vitro tissues, and alignment of cells under shear stress. This device has a high potential for applications in microfluidic devices and perfusion culture of cells. Abstract : This work proposes a 3D‐printed centrifugal pump driven by magnetic force. Precise control of the flow rate and a wide range and variety of flow profiles are achieved by controlling the rotational speed of the motor. Compact size enables simple setups within commercially available culture dishes and tubes. Moreover, demonstrations of laminar flow production and perfusion culture are presented for biological applications in microfluidic devices.