Transition‐Metal‐Free Heterobiaryl Synthesis via Aryne Coupling. Issue 31 (22nd March 2019)

• Record Type: Journal Article
• Authors: Saied, Tarak; Demangeat, Catherine; Panossian, Armen; Leroux, Frédéric R.; Fort, Yves; Comoy, Corinne
• Is Part Of: European journal of organic chemistry. Issue 31/32(2019)
• Page Start: 5275
• Page End: 5284
• Publication Date: 2019-03-22
• Subjects: Reaction mechanisms -- Heterocyclic chemistry -- Arynes -- Salt effect -- Ligand effects; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201900130
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : We disclose, for the first time, an efficient route for the construction of various heterobiaryl backbones in fair to excellent yields using the Aryne coupling methodology. This study outlined the remarkable effect of external chelating ligands and salt additives on the heterocyclic partner reactivity in the aryne coupling reaction. Abstract : For the first time, an efficient route for the construction of various heterobiaryl backbones in fair to excellent yields using the aryne coupling methodology is disclosed. This study outlined the remarkable effect of external chelating ligands and salt additives on the heterocyclic partner reactivity in this coupling reaction.