Palladium-catalyzed C(sp3)–H nitrooxylation of masked alcohols. Issue 1 (30th November 2022)

• Record Type: Journal Article
• Authors: Xue, Yuan; Zhou, Ruo-Bing; Luo, Jun; Hu, Bing-Cheng; Liu, Zhong-Quan; Jiang, Chao
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 1(2022)
• Page Start: 75
• Page End: 79
• Publication Date: 2022-11-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01919a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A palladium-catalyzed β-C(sp 3 )–H nitrooxylation of aliphatic alcohols with AgNO2 is reported. Various nitrooxylated alcohols could be obtained and converted into 1, 2-diol and 1, 2-amino alcohol. Abstract : A palladium-catalyzed β-C(sp 3 )–H nitrooxylation of aliphatic alcohols with AgNO2 is reported. An 8-formylquinoline-derived oxime is installed as an exo -type directing group for sp 3 C–H activation and selectfluor acts as the oxidant. The reaction tolerates a variety of functional groups and shows good selectivity for β-C–H nitrooxylation of alcohols.