Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations. Issue 1 (23rd November 2022)

• Record Type: Journal Article
• Authors: Kumar, Sanjeev; Borkar, Vaishnavi; Mujahid, Mohd.; Nunewar, Saiprasad; Kanchupalli, Vinaykumar
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 1(2022)
• Page Start: 24
• Page End: 38
• Publication Date: 2022-11-23
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01644c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : This review article summarizes the synthesis of iodonium ylides and its potential applications in C–H funtionalizations/annulations, including nitrogen heterocycles, oxygen heterocyles, alkenylations, etc . Abstract : The metal-catalyzed successive activation and functionalization of arene/heteroarene is one of the most fundamental transformations in organic synthesis and leads to privileged scaffolds in natural products, pharmaceuticals, agrochemicals, and fine chemicals. Particularly, transition-metal-catalyzed C–H functionalization of arenes with carbene precursors via metal carbene migratory insertion has been well studied. As a result, diverse carbene precursors have been evaluated, such as diazo compounds, sulfoxonium ylides, triazoles, etc . In addition, there have been significant developments with the use of iodonium ylides as carbene precursors in recent years, and these reactions proceed with high efficiencies and selectivities. This review provides a comprehensive overview of iodonium ylides in C–H functionalizations, including the scope, limitations, and their potential synthetic applications.