Mitochondrial transplantation in cardiac surgical patients: optimism, caveats, and outstanding questions. Issue 1 (20th February 2023)

• Record Type: Journal Article
• Authors: Cherry, Anne D.
• Is Part Of: Current opinion in anaesthesiology. Volume 36:Issue 1(2023)
• Page Start: 5
• Page End: 10
• Publication Date: 2023-02-20
• Subjects: cardiac surgery -- ischemia/reperfusion injury -- mitochondrial transplantation; Anesthesiology -- Periodicals; Anesthesiology -- Indexes; Anesthesiology -- Periodicals; Review Literature -- Indexes; Review Literature -- Periodicals; Anesthesiology; Periodicals; 617.9605
• DOI: 10.1097/ACO.0000000000001202
• Languages: English
• ISSNs: 0952-7907

Abstract

Abstract : Purpose of review: Mitochondria satisfy the high metabolic demand of the heart, and also play major roles in reactive oxygen species signaling, calcium buffering, and regulation of cell death. Mitochondrial damage or dysfunction can drive diseases seen in cardiac surgical patients, including heart failure and ischemia/reperfusion injury. Exogenous transplantation of isolated mitochondria has been proposed as one way to augment mitochondrial function and mitigate a number of pathologic processes, with a heavy focus on ischemia/reperfusion injury. Recent findings: Animal models of cardiac ischemia/reperfusion injury have shown functional benefits after mitochondrial transplantation. Many of the mechanisms underlying this therapy's effect; optimal dosing, delivery, and timing; and how it will translate to cardiac surgical patients are yet unknown. Summary: Mitochondrial transplantation is a potential therapeutic strategy for cardiac ischemia/reperfusion injury. Effective application to selected cardiac surgical patients can be informed by further mechanistic investigations.