Treatment and resource utilization for menopausal symptoms in the United States: a retrospective review of real-world evidence from US electronic health records. Issue 1 (20th January 2023)

• Record Type: Journal Article
• Authors: DePree, Barbara; Houghton, Katherine; Shiozawa, Aki; Esterberg, Elizabeth; King, Deanna D.; Kim, Janet; Mancuso, Shayna
• Is Part Of: Menopause. Volume 30:Issue 1(2023)
• Page Start: 70
• Page End: 79
• Publication Date: 2023-01-20
• Subjects: Health care resource utilization -- Hot flashes -- Menopause -- Night sweats -- Retrospective medical record review -- Vasomotor symptoms; Menopause -- Periodicals; 618.175005
• DOI: 10.1097/GME.0000000000002095
• Languages: English
• ISSNs: 1072-3714

Abstract

Abstract : A high proportion of women with vasomotor symptoms (VMSs) remain untreated even when experiencing bothersome symptoms of menopause status. Improved management of VMSs is required to provide relief from the symptoms effectively and safely. Abstract: Objective: The aim of this study was to generate real-world evidence documenting use of prescription and nonprescription therapies recorded by health care providers for women experiencing vasomotor symptoms (VMS) associated with menopause. Methods: This noninterventional, retrospective, observational cohort study used data from US patient medical records. Participating health care providers were gynecologists, internal medicine/family physicians, or advanced practice providers who typically saw three or more women per week presenting with menopausal symptoms and could identify eligible medical records; providers were recruited from local medical association directories and from listings from previously conducted research. Eligible women presented January 2016 through December 2019, were 40 to 60 years of age, and reported experiencing bothersome hot flashes at least twice within 24 hours. Results: A total of 283 health care providers provided data for 1, 016 women. The most common symptoms at initial presentation were hot flashes (91.2%), sleep problems (49.9%), and vaginal dryness (47.0%). At least one therapy for menopausal symptoms was recorded for 883 women (86.9%), and 611 (60.1%) had documentation of prescription medication, most commonly hormone therapy (70.4%). Nearly 40% of women had no prescription medication documented, and approximately 13% had no therapy documented. Despite experiencing bothersome menopausal symptoms, approximately 50% delayed seeking care for more than 6 months. Women had a mean of 2.1 (SD, 2.0) office visits related to menopause from initial presentation to completion of review, and health care resource utilization did not vary by treatment status. Subgroup analyses indicated nominal differences in treatment use across ethnic groups and varying prescribing patterns for menopausal symptoms by practitioner type and US region. Conclusions: A high proportion of women with VMS remain untreated even when experiencing bothersome symptoms of menopause. Improved management of VMS is required to provide relief from the symptoms effectively and safely.