Primary antibody deficiency-associated arthritis shares features with spondyloarthritis and enteropathic arthritis. Issue 2 (6th December 2022)

• Record Type: Journal Article
• Authors: Pott, Nina Mee; Atschekzei, Faranaz; Pott, Carl Christoph; Ernst, Diana; Witte, Torsten; Sogkas, Georgios
• Is Part Of: RMD open. Volume 8:Issue 2(2022)
• Publication Date: 2022-12-06
• Subjects: Arthritis -- Spondylitis, Ankylosing -- Autoimmunity -- Immune System Diseases; Musculoskeletal system -- Diseases -- Periodicals; Rheumatism -- Periodicals; 616.7005
• DOI: 10.1136/rmdopen-2022-002664
• Languages: English
• ISSNs: 2056-5933

Abstract

Abstract : Objective: The clinical spectrum of primary antibody deficiencies (PADs) and especially common variable immunodeficiency (CVID) includes various autoimmune disorders. We studied the prevalence and the features of articular rheumatic disease in a cohort of patient with PADs. Methods: In this retrospective cohort study, complete clinical data of 268 patients with PADs, mainly consisting of patients with CVID, visiting the immunology outpatient clinic of a German tertiary hospital between 2018 and 2021 were collected. Those included case history, physical examination, laboratory as well as radiological findings. Results: Inflammatory arthritis was diagnosed in 16.4% of studied patients and was significantly more common among patients with PAD-associated enteropathy (OR 13.39, p=0.0001), splenomegaly (OR 6.09, p=0.0001) or atopic diseases (OR 3.31, p=0.021). Given HLA-B27 status, the involvement of the axial skeleton and the presence of features, such as anterior uveitis, inflammatory bowel disease, psoriasis and/or dactylitis, 75% of studied patients fulfilled the Assessment of Spondyloarthritis International Society classification criteria. Conclusion: PAD-associated arthritis frequently shares features with spondyloarthritis (SpA) and enteropathic arthritis. The latter may suggest the interconnected pathomechanisms of inflammatory arthritis in SpA and PADs.