Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals. (1st May 2016)

• Record Type: Journal Article
• Authors: Kock, M.; Coenraads, P.‐J.; Blömeke, B.; Goebel, C.
• Is Part Of: British journal of dermatology. Volume 174:Number 5(2016)
• Page Start: 1042
• Page End: 1050
• Publication Date: 2016-05-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.14390
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Background: Despite a positive patch test reaction to para ‐phenylenediamine (PPD) and/or toluene‐2, 5‐diamine (PTD), many people attempt to continue dyeing their hair with products containing PPD or its derivatives. Objectives: Investigation of elicitation reactions among PPD/PTD‐allergic individuals to hair dye products containing the less sensitizing PPD derivative 2‐methoxymethyl (ME)‐PPD. Methods: Elicitation reactions were studied in 43 PPD/PTD‐allergic individuals by a 45‐min pretest with an ME‐PPD‐containing hair dye on their forearm. Upon a negative result this was followed by exposure to subsequent hair colour treatment(s). Results: Overall, 38 of 43 PPD/PTD‐allergic individuals did not develop an elicitation reaction during the pretest with ME‐PPD‐containing hair dye products, and were eligible for subsequent hair colour treatments. Of these 38 PPD/PTD‐allergic individuals, 29 tolerated subsequent hair dyeing with ME‐PPD‐containing hair dye products, while seven showed mild and two showed moderate/marked allergic reactions upon the first hair colour treatment. Conclusions: Hair dye products with the less sensitizing ME‐PPD were tolerated by 29 of 43 (67%) PPD/PTD‐allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild‐to‐moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD/PTD‐allergic individuals indicating that a negative 45‐min pretest with a hair dye product helps to avoid severe allergic reactions.