Role of TCF‐1 in differentiation, exhaustion, and memory of CD8+ T cells: A review. Issue 5 (29th April 2021)

• Record Type: Journal Article
• Authors: Zhang, Jiaxue; Lyu, Tong; Cao, Yaming; Feng, Hui
• Is Part Of: FASEB journal. Volume 35:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-29
• Subjects: cancer -- CD8+ T cells -- exhaustion -- immune memory -- TCF‐1 -- viral Infection; Biology -- Periodicals; Biology, Experimental -- Periodicals; 570
• DOI: 10.1096/fj.202002566R
• Languages: English
• ISSNs: 0892-6638

Abstract

Abstract: T cell factor‐1 (TCF‐1) (encoded by the TCF7 gene) is a transcription factor that plays important role during the T cell development and differentiation for T cell to exercise its functions including producing memory T cells. Not only TCF‐1 can modulate the T cell development but also exerts various effects on the differentiation and function of mature CD8 + T cells. In addition, it drives the production and maintenance of the immune response of CD8 + T cells after PD‐1 checkpoint blockade therapy. TCF‐1 can serve as a potential target of immunotherapy and may provide promising novel treatment strategies for patients with cancer and infections. Moreover, TCF‐1 is a potential biomarker of CD8 + T cell functionality to predict the efficacy of immunotherapy in fighting against cancer and infections. Herein, we summarize the role of TCF‐1 in T cell development and its applications in the treatment of cancer and infectious diseases.