Genetic overlap between temporomandibular disorders and primary headaches: A systematic review. (November 2022)

• Record Type: Journal Article
• Authors: Cruz, Diogo; Monteiro, Francisca; Paço, Maria; Vaz-Silva, Manuel; Lemos, Carolina; Alves-Ferreira, Miguel; Pinho, Teresa
• Is Part Of: Japanese dental science review. Volume 58(2022)
• Page Start: 69
• Page End: 88
• Publication Date: 2022-11
• Subjects: Genetics -- Migraine -- Primary headache -- Single-nucleotide polymorphism -- Systematic review -- Temporomandibular disorders; COMT catechol-O-methyltransferase -- ESR1 estrogen receptor 1 -- GWAS genome-wide association studies -- MTHFR methylenetetrahydrofolate reductase -- PHD primary headache disorders -- PICOS Population, Intervention, Comparison, Outcomes and Study design -- PRISMA Preferred Reporting Items for Systematic Review and Meta-analysis -- TMD temporomandibular disorders -- TMJ temporomandibular joint; Dentistry -- Periodicals; Dentistry -- Japan -- Periodicals; 617.6005
• DOI: 10.1016/j.jdsr.2022.02.002
• Languages: English
• ISSNs: 1882-7616

Abstract

Abstract: Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were COMT, MTHFR, and ESR1. COMT was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of MTHFR gene regulation on either TMD or PHD was found. The most robust results are concerning the ESR1 gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of ESR1 and COMT genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.