A Case of Poorly Differentiated Synovial Sarcoma Arising in a Nasal Cavity Radiation Field: An Unusual Tumor in an Unusual Location. (February 2023)

• Record Type: Journal Article
• Authors: Jobbagy, Soma; Bilek, Melissa; You, Bei; Shah, Maya; Jobbagy, Zsolt
• Is Part Of: International journal of surgical pathology. Volume 31:Number 1(2023)
• Page Start: 76
• Page End: 81
• Publication Date: 2023-02
• Subjects: synovial sarcoma -- sinonasal -- radiation -- SS18::SSX; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/10668969221098092
• Languages: English
• ISSNs: 1066-8969

Abstract

Synovial sarcomas are high-grade soft tissue sarcomas of primitive mesenchymal origin which are defined by a pathognomonic t(X;18)(p11, q11) translocation, and which occur in pediatric and adult populations. Herein we report a case of a 33-year-old female with a history of nasopharyngeal carcinoma status post radiotherapy, presenting with a poorly differentiated synovial sarcoma of the nasal cavity arising in the radiation field. While the development of radiation-associated sarcoma is a known complication of radiotherapy, to date only 10 cases of synovial sarcoma have been reported to occur in previously irradiated tissues. Moreover, only 1 case of poorly differentiated synovial sarcoma involving the nasopharynx has been described.