Assessment of prognostic and reproductive outcomes of omentectomy for patients with clinically apparent early‐stage (I, II) malignant ovarian germ cell tumours: A multicentre retrospective study. (9th December 2022)

• Record Type: Journal Article
• Authors: Liu, Penglin; Li, Zhuang; Cheng, Xiaodong; Gao, Qinglei; Che, Yanci; Zhang, Zhaoyang; Chu, Ran; Chen, Zhongshao; Zhang, Yue; Wang, Qiannan; Dou, Zhiyuan; Wei, Yuan; Cui, Zhumei; Wang, Jianliu; Xie, Xing; Ma, Ding; Yang, Xingsheng; Kong, Beihua; Song, Kun
• Other Names: Ma Ding guestEditor.; Gao Qinglei guestEditor.
• Is Part Of: BJOG. Volume 129(2022)Supplement 2
• Page Start: 23
• Page End: 31
• Publication Date: 2022-12-09
• Subjects: clinically apparent early stage -- malignant ovarian germ cell tumours -- omentectomy -- prognostic outcomes -- propensity score matching -- reproductive outcomes; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.17325
• Languages: English
• ISSNs: 1470-0328

Abstract

Abstract: Objective: This study assessed the effect of omentectomy on the prognosis and fertility in patients with clinically early‐stage (I, II) malignant ovarian germ cell tumours (MOGCT). Design: A retrospective multicentre study. Setting: Four university teaching hospitals in China. Population: A total of 268 patients with clinically apparent early‐stage (I, II) MOGCT. Methods: Data were obtained from the medical records. Additionally, the propensity score matching (PSM) algorithm was adopted. Main outcome measures: Prognostic outcomes were disease‐free survival (DFS) and overall survival (OS). Fertility outcomes were pregnancy and live birth rates. Results: A total of 187 (69.8%) patients underwent omentectomy. Kaplan–Meier analysis showed no significant differences in DFS and OS between the omentectomy and non‐omentectomy groups before and after PSM ( p > 0.05). Additionally, subgroup analysis stratified by age (<18 and ≥18 years) showed similar results. International Federation of Gynecology and Obstetrics (FIGO) stage was the only risk factor associated with DFS (hazard ratio [HR] 14.71, 95% confidence interval [CI] 4.47–48.38, p < 0.001) and OS (HR 37.36, 95% CI 3.87–361.16, p = 0.002). Pregnancy and live birth rates in the total population were 80.3% and 66.7%, respectively. There were no significant differences between the two groups before and after PSM. Conclusions: Omentectomy did not improve survival or affect fertility in patients with clinically apparent early‐stage (I, II) MOGCT, regardless of the age. The clinical FIGO stage was an independent risk factor for recurrence and death.