Dose–response curves for co-exposure inhalation challenges with ozone and pollen allergen. Issue 2 (22nd August 2019)

• Record Type: Journal Article
• Authors: Ørby, Pia Viuf; Bønløkke, Jakob Hjort; Bibby, Bo Martin; Ravn, Peter; Hertel, Ole; Sigsgaard, Torben; Schlünssen, Vivi
• Is Part Of: European respiratory journal. Volume 54:Issue 2(2019)
• Publication Date: 2019-08-22
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01208-2018
• Languages: English
• ISSNs: 0903-1936

Abstract

Exposures to pollen and air pollutants commonly occur simultaneously and have been linked to eliciting or exacerbating the allergic response in susceptible individuals [1, 2]. The risk of co-exposure was recently confirmed in a study from Copenhagen, Denmark [3] indicating that pollen and ozone concentration peaks coincide both diurnally and seasonally. Ozone exposures are able to prime the airways and exacerbate respiratory symptoms [4]. However, this effect is debated, especially regarding lower and more commonly naturally occurring exposures [5, 6]. Exposure to low, naturally occurring, levels of ozone do not alter the bronchial response profile to pollen allergen, or lower the PD20 in atopic individuals, estimated by applying a novel non-linear model approach http://bit.ly/2XQjzw I