Characteristics and treatment regimens across ERS SHARP severe asthma registries. Issue 1 (9th January 2020)

• Record Type: Journal Article
• Authors: van Bragt, Job J.M.H.; Adcock, Ian M.; Bel, Elisabeth H.D.; Braunstahl, Gert-Jan; ten Brinke, Anneke; Busby, John; Canonica, Giorgio W.; Cao, Hui; Chung, Kian Fan; Csoma, Zsuzsanna; Dahlén, Barbro; Davin, Elizabeth; Hansen, Susanne; Heffler, Enrico; Horvath, Ildiko; Korn, Stephanie; Kots, Maxim; Kuna, Piotr; Kwon, Namhee; Louis, Renaud; Plaza, Vicente; Porsbjerg, Celeste; Ramos-Barbon, David; Richards, Levi B.; Škrgat, Sabina; Sont, Jacob K.; Vijverberg, Susanne J.H.; Weersink, Els J.M.; Yasinska, Valentyna; Wagers, Scott S.; Djukanovic, Ratko; Maitland-van der Zee, Anke H.;
• Other Names: author non-byline.; Abenhardt B. author non-byline.; Adcock I.M. author non-byline.; Adler J. author non-byline.; Alfonso R. author non-byline.; Ali R. author non-byline.; Alkameh S. author non-byline.; Almonacid Sánchez C. author non-byline.; Alvares L. author non-byline.; Anderson G. author non-byline.; Assing K. author non-byline.; Ayre S. author non-byline.; Becker J. author non-byline.; Bel E.H.D. author non-byline.; Bergmann K. author non-byline.; Bieksiene K. author non-byline.; Bjerring N. author non-byline.; Blasi F. author non-byline.; Bloemen P. author non-byline.; Blum H. author non-byline.; Böing S. author non-byline.; Bonavia M. author non-byline.; Bossios A. author non-byline.; Bourdin A. author non-byline.; Braunstahl G-J. author non-byline.; Brons A. author non-byline.; Brusselle G. author non-byline.; Buis J. author non-byline.; Busby J. author non-byline.; Caiaffa M. author non-byline.; Calabrese C. author non-byline.; Camiciottoli G. author non-byline.; Canonica G.W. author non-byline.; Cao H. author non-byline.; Caruso C. author non-byline.; Castilla Martínez M. author non-byline.; Centanni S. author non-byline.; Chung K.F. author non-byline.; Cisneros Serrano C. author non-byline.; Corsico A. author non-byline.; Cosmi L. author non-byline.; Costantino M. author non-byline.; Costello R. author non-byline.; Crimi N. author non-byline.; Csoma Z. author non-byline.; Dahlen S. author non-byline.; Dahlén B. author non-byline.; D'Amato M. author non-byline.; Davies D. author non-byline.; Davin E. author non-byline.; de Borja García-Cosío Piqueras F. author non-byline.; Decarlo G. author non-byline.; Deimling A. author non-byline.; Del Giacco S. author non-byline.; Diaz Campos R. author non-byline.; Djandji M. author non-byline.; Djukanovic R. author non-byline.; Doberer D. author non-byline.; Dupont L. author non-byline.; Dyett K. author non-byline.; Edelbaher N. author non-byline.; Edelmann M. author non-byline.; Ehmann R. author non-byline.; Ekberg-Jansson A. author non-byline.; Farsi A. author non-byline.; Favero E. author non-byline.; Feimer J. author non-byline.; Fletcher M. author non-byline.; Foschino B. author non-byline.; Frankemölle B. author non-byline.; Gaga M. author non-byline.; Gappa M. author non-byline.; García de Pedro J. author non-byline.; García Rivero J. author non-byline.; Gasplmayr M. author non-byline.; Gebhardt R. author non-byline.; Geldmacher H. author non-byline.; Geltner C. author non-byline.; Gerstlauer M. author non-byline.; Gibson T. author non-byline.; Giuseppe G. author non-byline.; Gogoll C. author non-byline.; Grimm-Sachs V. author non-byline.; Grisle I. author non-byline.; Grün B. author non-byline.; Grünewaldt A. author non-byline.; Guarnieri G. author non-byline.; Gullón Blanco J. author non-byline.; Hamelmann E. author non-byline.; Hamerlijnck D. author non-byline.; Hammers-Reinhard A. author non-byline.; Hanon S. author non-byline.; Hansen S. author non-byline.; Harzheim D. author non-byline.; Heaney L. author non-byline.; Heffler E. author non-byline.; Hellmich S. author non-byline.; Herden M. author non-byline.; Hering T. author non-byline.; Herth F. author non-byline.; Hilberg O. author non-byline.; Horvath I. author non-byline.; Howarth P. author non-byline.; Hubatsch M. author non-byline.; Humbert M. author non-byline.; Husemann K. author non-byline.; Idzko M. author non-byline.; Jackson D. author non-byline.; Jandl M. author non-byline.; Jaumont X. author non-byline.; Joos G. author non-byline.; Jöst M. author non-byline.; Jüch M. author non-byline.; Kabesch M. author non-byline.; Kaiser-Labusch P. author non-byline.; Kardos P. author non-byline.; Käßner F. author non-byline.; Keeley T. author non-byline.; Kerr W. author non-byline.; Kirschner J. author non-byline.; Klimek L. author non-byline.; Koca M. author non-byline.; Koczulla R. author non-byline.; Koerner-Rettberg C. author non-byline.; Kopac P. author non-byline.; Korn S. author non-byline.; Korn S. author non-byline.; Kots M. author non-byline.; Kronsbein J. author non-byline.; Kuna P. author non-byline.; Kupryś Lipinska I. author non-byline.; Kwon N. author non-byline.; Langer M. author non-byline.; Langeveld B. author non-byline.; Lantz A. author non-byline.; Lazarinis N. author non-byline.; Lazic Z. author non-byline.; Lehtimäki L. author non-byline.; Leuppi J. author non-byline.; Lombardi C. author non-byline.; Lommatzsch M. author non-byline.; López-Viña A. author non-byline.; Louis R. author non-byline.; Luca R. author non-byline.; Lúðvíksdóttir D. author non-byline.; Lüttecke-Hecht C. author non-byline.; Macchia L. author non-byline.; Magni T. author non-byline.; Maitland-van der Zee A.H. author non-byline.; Martínez Rivera C. author non-byline.; Mastoridis P. author non-byline.; Mazza F. author non-byline.; Menzella F. author non-byline.; Menzies-Gow A. author non-byline.; Michils A. author non-byline.; Mihălţan F. author non-byline.; Milanese M. author non-byline.; Milger-Kneidinger K. author non-byline.; Molinska J. author non-byline.; Montagna I. author non-byline.; Montuschi P. author non-byline.; Mülleneisen N. author non-byline.; Muñoz Esquerre M. author non-byline.; Nanzer-Kelly A. author non-byline.; Nenasheva N. author non-byline.; Neurohr C. author non-byline.; Nucera E. author non-byline.; Otker J. author non-byline.; Oud K. author non-byline.; Paggiaro P. author non-byline.; Parente R. author non-byline.; Parkinson J. author non-byline.; Passalacqua G. author non-byline.; Patberg N. author non-byline.; Patella V. author non-byline.; Patino O. author non-byline.; Paulsson T. author non-byline.; Peche R. author non-byline.; Pelaia G. author non-byline.; Peress E. author non-byline.; Pérez de Llano L. author non-byline.; Pfeffer P. author non-byline.; Pfister P. author non-byline.; Pilette C. author non-byline.; Pinedo Sierra C. author non-byline.; Pini L. author non-byline.; Plaza V. author non-byline.; Porsbjerg C. author non-byline.; Powitz F. author non-byline.; Ramos-Barbon D. author non-byline.; Ranger T. author non-byline.; Rasmussen L. author non-byline.; Rasmussen K. author non-byline.; Rezelj M. author non-byline.; Ricciardi L. author non-byline.; Ricciardolo F. author non-byline.; Richards L.B. author non-byline.; Ridolo E. author non-byline.; Rijssenbeek-Nouwens L. author non-byline.; Rolla G. author non-byline.; Romero Ribate D. author non-byline.; Rüdiger S. author non-byline.; Safioti G. author non-byline.; Sandström T. author non-byline.; Santus P. author non-byline.; Sauer R. author non-byline.; Schauerte G. author non-byline.; Schipmann R. author non-byline.; Schleich F. author non-byline.; Schmid J. author non-byline.; Schmidt F. author non-byline.; Schmidt O. author non-byline.; Schmitz M. author non-byline.; Schrag T. author non-byline.; Schröer S. author non-byline.; Schultz K. author non-byline.; Schulz C. author non-byline.; Scichilone N. author non-byline.; Sedlak V. author non-byline.; Selb J. author non-byline.; Senna G. author non-byline.; Sergejeva S. author non-byline.; Serrano Pariente J. author non-byline.; Sichau M. author non-byline.; Simona D. author non-byline.; Singer A. author non-byline.; Skowasch D. author non-byline.; Škrgat S. author non-byline.; Smeenk F. author non-byline.; Smith S. author non-byline.; Sont J.K. author non-byline.; Spadaro G. author non-byline.; Spanevello A. author non-byline.; Stefansdottir M. author non-byline.; Steinmetz K. author non-byline.; Steiß J. author non-byline.; Stephan M. author non-byline.; Stieglitz S. author non-byline.; Suhling H. author non-byline.; Taube C. author non-byline.; ten Brinke A. author non-byline.; Tolga Yavuz S. author non-byline.; Tudoric N. author non-byline.; Ulrik C. author non-byline.; van Bragt J.J.M.H. author non-byline.; van de Ven M. author non-byline.; van den Elshout F. author non-byline.; Van Dyke M. author non-byline.; van Nederveen-Bendien S. author non-byline.; van Veen I. author non-byline.; Vandenplas O. author non-byline.; Velthove K. author non-byline.; Vianello A. author non-byline.; Vijverberg H.S.J. author non-byline.; Vogelberg C. author non-byline.; Wagers S.S. author non-byline.; Wallén-Nielsen E. author non-byline.; Weersink E.J. author non-byline.; Wisskirchen T. author non-byline.; Yacoub M. author non-byline.; Yancey S. author non-byline.; Yasinska V. author non-byline.; Zappa M. author non-byline.; Zielen S. author non-byline.; Zimmermann C. author non-byline.; Zimmermann R. author non-byline.;
• Is Part Of: European respiratory journal. Volume 55:Issue 1(2020)
• Publication Date: 2020-01-09
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01163-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals. This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases. Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg·m −2 (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 µg·day −1 between those from Slovenia versus Poland when starting anti-interleukin (IL)-5 antibody and from 772 to 1344 µg·day −1 in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively. The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries. The severe asthma population in Europe is heterogeneous and differs in clinical characteristics and treatment. Harmonisation across registries and guidelines is needed and requires collection of same data across cohorts to enable future research in SHARP. http://bit.ly/2krxHPf