Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs. Issue 1 (16th January 2020)

• Record Type: Journal Article
• Authors: Arndal, Elisabeth; Johansen, Helle K.; Haagensen, Janus A.J.; Bartell, Jennifer A.; Marvig, Rasmus L.; Alanin, Mikkel; Aanæs, Kasper; Høiby, Niels; Nielsen, Kim G.; Backer, Vibeke; von Buchwald, Christian
• Is Part Of: European respiratory journal. Volume 55:Issue 1(2020)
• Publication Date: 2020-01-16
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01472-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Similar to patients with cystic fibrosis (CF) and non-CF bronchiectasis, patients with primary ciliary dyskinesia (PCD) are prone to recurrent or chronic lung infections with Pseudomonas aeruginosa . Chronic P. aeruginosa lung infection has a prevalence of up to 39% in patients with PCD [1] and is associated with structural damage, affecting lung function. Treatment of P. aeruginosa infection is challenging because P. aeruginosa adapts to the host environment through genotypic/phenotypic changes, promoting a reduced immune response [2]. For the first time it is shown that the same Pseudomonas aeruginosa clone exists in both the upper and lower airways in patients with PCD, providing a solid support of the unified airway theory where the sinuses are a possible bacterial reservoir http://bit.ly/2kcE9tq