C1-esterase inhibitor treatment for antibody-mediated rejection after lung transplantation: two case reports. Issue 4 (16th April 2020)

• Record Type: Journal Article
• Authors: Parquin, François; Cuquemelle, Elise; Camps, Eve; Devaquet, Jérôme; Phillips Houllbracq, Mathilde; Sage, Edouard; Brugière, Olivier; Le Guen, Morgan; Longchampt, Elisabeth; Malard, Stéphanie; Picard, Clément; Taupin, Jean Luc; Roux, Antoine
• Is Part Of: European respiratory journal. Volume 55:Issue 4(2020)
• Publication Date: 2020-04-16
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02027-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Antibody-mediated rejection (AMR) after lung transplantation (LTx) is associated with poor prognosis [1]. Recent International Society for Heart and Lung Transplantation recommendations propose a standardised classification of lung AMR [2]. Based on the number of features present, this classification describes three different degree of certainty for AMR diagnosis. However, in the absence of a true gold standard, the management of potential AMR are subject to quite a high degree of uncertainty. C1 esterase inhibitor could be efficient in complement dependent antibody mediated rejection in lung transplant patients http://bit.ly/2Nsz6R4