Antinuclear antibodies and subclinical interstitial lung disease in community-dwelling adults: the MESA study. Issue 4 (16th April 2020)

• Record Type: Journal Article
• Authors: Bernstein, Elana J.; Austin, John H.M.; Kawut, Steven M.; Raghu, Ganesh; Hoffman, Eric A.; Newell, John D.; Watts, Jubal R.; Nath, P. Hrudaya; Sonavane, Sushilkumar K.; Barr, R. Graham; Lederer, David J.
• Is Part Of: European respiratory journal. Volume 55:Issue 4(2020)
• Publication Date: 2020-04-16
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02262-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

The presence of a systemic autoimmune rheumatic disease (ARD) is a well-known risk factor for interstitial lung disease (ILD). For example, 33% of adults with rheumatoid arthritis (RA) have subclinical ILD [1]. Higher serum levels of IgM rheumatoid factor (RF), IgA RF, and anti-cyclic citrullinated peptide antibody 2 are associated with subclinical ILD in community-dwelling adults [2]. It is unknown whether this relationship between autoimmunity and subclinical ILD is limited to RA-related autoantibodies, or extends more broadly to other epitopes. High attenuation areas (HAA) and interstitial lung abnormalities (ILA) are validated quantitative and qualitative subclinical ILD phenotypes, respectively. In community-dwelling adults, greater HAA is associated with reduced forced vital capacity, reduced exercise capacity, elevated serum levels of matrix metalloproteinase-7 and interleukin-6, higher prevalence of ILA on computed tomography (CT) scans of the chest, higher all-cause mortality rate, and an increased risk of developing clinically evident ILD and ILD-specific mortality at 12-year follow-up [3, 4]. ILA has been associated with all-cause mortality in four different longitudinal cohorts [5]. The purpose of this study was to examine the association between antinuclear antibody (ANA) and both HAA and ILA in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Antinuclear antibodies are associated with subclinical interstitial lung disease in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis http://bit.ly/2FIEJpS