The MUC5B promoter risk allele for idiopathic pulmonary fibrosis predisposes to asbestosis. Issue 4 (29th April 2020)

• Record Type: Journal Article
• Authors: Platenburg, Mark G.J.P.; Wiertz, Ivo A.; van der Vis, Joanne J.; Crestani, Bruno; Borie, Raphael; Dieude, Philippe; Kannengiesser, Caroline; Burgers, Jacobus A.; Grutters, Jan C.; van Moorsel, Coline H.M.
• Is Part Of: European respiratory journal. Volume 55:Issue 4(2020)
• Publication Date: 2020-04-29
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02361-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Asbestosis is a fibrosing interstitial pneumonitis, which can develop following occupational asbestos exposure and a lengthy latency period [1]. Even after strict regulations on the asbestos industry, an estimated 3400 individuals worldwide died as a consequence of asbestosis in 2017 [2]. The minor allele of MUC5B rs35705950 predisposes to asbestosis, but has no effect on survival http://bit.ly/382gPBM