Predictors of parenchymal hemorrhage after endovascular treatment in acute ischemic stroke: data from ANGEL-ACT Registry. (12th January 2022)

• Record Type: Journal Article
• Authors: Sun, Dapeng; Jia, Baixue; Tong, Xu; Kan, Peter; Huo, Xiaochuan; Wang, Anxin; Raynald, ; Ma, Gaoting; Ma, Ning; Gao, Feng; Mo, Dapeng; Song, Ligang; Sun, Xuan; Liu, Lian; Deng, Yiming; Li, Xiaoqing; Wang, Bo; Luo, Gang; Wang, Yongjun; Ren, Zeguang; Miao, Zhongrong
• Other Names: author non-byline.; Miao Zhongrong author non-byline.; Gui Liqiang author non-byline.; Peng Cunfeng Song Ya author non-byline.; Wu Jin author non-byline.; Zhao Shijun author non-byline.; Zhao Junfeng author non-byline.; Zhou Zhiming author non-byline.; Li Yongli author non-byline.; Jing Ping author non-byline.; Yang Lei author non-byline.; Liu Yajie author non-byline.; Zhao Qingshi author non-byline.; Liu Yan author non-byline.; Peng Xiaoxiang author non-byline.; Gao Qingchun author non-byline.; Guo Zaiyu author non-byline.; Chen Wenhuo author non-byline.; Li Weirong author non-byline.; Cheng Xiaojiang author non-byline.; Xu Yun author non-byline.; Zhang Yongqiang author non-byline.; Zhang Guilian author non-byline.; Lu Yijiu author non-byline.; Lu Xinyu author non-byline.; Wang Dengxiang author non-byline.; Wang Yan author non-byline.; Hua Hao LiYang author non-byline.; Geng Deqin author non-byline.; Yuan Haicheng author non-byline.; Wang Hongwei author non-byline.; Yang Haihua author non-byline.; Wang Zengwu author non-byline.; Wei Liping author non-byline.; Liufu Xuancong author non-byline.; Li Xiangqun ShiJuntao author non-byline.; Yang Wenwu author non-byline.; Jing Wenji author non-byline.; Xiang Yong MD author non-byline.; Wang Leyuan author non-byline.; Li Chunlei author non-byline.; Cao Yibin author non-byline.; Zhu Qingfeng author non-byline.; Zhang Peng author non-byline.; Luo Xiang author non-byline.; Chen Shengli author non-byline.; Peng WenWu author non-byline.; Wang Lixin author non-byline.; Wen Xue author non-byline.; Shi Shugui author non-byline.; Wang Wanming author non-byline.; Bo Wang author non-byline.; Yuan Pu author non-byline.; Wang Dong author non-byline.; Guan Haitao author non-byline.; Liang Wenbao author non-byline.; Ma Daliang author non-byline.; Chen Long author non-byline.; Xiao Yan author non-byline.; Xie Xiangdong author non-byline.; Shi Zhonghua author non-byline.; Zeng Xiangjun author non-byline.; Su Fanfan author non-byline.; Chang MingZe author non-byline.; Yin Jijun author non-byline.; Sun Hongxia author non-byline.; Li Chong author non-byline.; Bi Yong author non-byline.; Xie Gang author non-byline.; Zhao Yuwu author non-byline.; Wang Chao author non-byline.; Zhang Peng author non-byline.; Wang Xianjun author non-byline.; Li Dongqun author non-byline.; Liang Hui author non-byline.; Chen Zhonglun author non-byline.; Wang Yan author non-byline.; Xin Yu author non-byline.; Wang Dengxiang author non-byline.; Yin Lin author non-byline.; Qiu HongKai author non-byline.; Wei Jun author non-byline.; Sun Yaxuan author non-byline.; Feng Xiaoya author non-byline.; Wu Weihua author non-byline.; Gao Lianbo author non-byline.; Ai Zhibing author non-byline.; Lan Tan author non-byline.; Li Ding Qilong Liang author non-byline.; Wang Zhimin author non-byline.; Yang Jianwen author non-byline.; Xu Ping author non-byline.; Dong Wei author non-byline.; Zheng Quanle author non-byline.; Zhu Zhenyun author non-byline.; Zhao Liyue author non-byline.; Meng Qingbo author non-byline.; Wei Yuqing author non-byline.; Wang Xianglin ChenWei author non-byline.; Sun Dong author non-byline.; Yan Yongxing author non-byline.; Yuan Guangxiong author non-byline.; Yang Yadong author non-byline.; Zhou Jianfeng author non-byline.; Yang Zhi author non-byline.; Zhang Zhenzhong author non-byline.; Guan Ning author non-byline.; Wang Huihong author non-byline.;
• Is Part Of: Journal of neurointerventional surgery. Volume 15:Number 1(2023)
• Page Start: 20
• Page End: 26
• Publication Date: 2022-01-12
• Subjects: stroke -- hemorrhage -- thrombectomy; Nervous system -- Surgery -- Periodicals; Cerebrovascular disease -- Surgery -- Periodicals; 617.48
• DOI: 10.1136/neurintsurg-2021-018292
• Languages: English
• ISSNs: 1759-8478

Abstract

Abstract : Background: Parenchymal hemorrhage (PH) is a troublesome complication after endovascular treatment (EVT). Objective: To investigate the incidence, independent predictors, and clinical impact of PH after EVT in patients with acute ischemic stroke (AIS) due to anterior circulation large vessel occlusion (LVO). Methods: Subjects were selected from the ANGEL-ACT Registry. PH was diagnosed according to the European Collaborative Acute Stroke Study classification. Logistic regression analyses were performed to determine the independent predictors of PH, as well as the association between PH and 90-day functional outcome assessed by modified Rankin Scale (mRS) score. Results: Of the 1227 enrolled patients, 147 (12.0%) were diagnosed with PH within 12–36 hours after EVT. On multivariable analysis, low admission Alberta Stroke Program Early CT score (ASPECTS)(adjusted OR (aOR)=1.13, 95% CI 1.02 to 1.26, p=0.020), serum glucose >7 mmol/L (aOR=1.82, 95% CI 1.16 to 2.84, p=0.009), and neutrophil-to-lymphocyte ratio (NLR; aOR=1.05, 95% CI 1.02 to 1.09, p=0.005) were associated with a high risk of PH, while underlying intracranial atherosclerotic stenosis (ICAS; aOR=0.42, 95% CI 0.22 to 0.81, p=0.009) and intracranial angioplasty/stenting (aOR=0.37, 95% CI 0.15 to 0.93, p=0.035) were associated with a low risk of PH. Furthermore, patients with PH were associated with a shift towards to worse functional outcome (mRS score 4 vs 3, adjusted common OR (acOR)=2.27, 95% CI 1.53 to 3.38, p<0.001). Conclusions: In Chinese patients with AIS caused by anterior circulation LVO, the risk of PH was positively associated with low admission ASPECTS, serum glucose >7 mmol/L, and NLR, but negatively related to underlying ICAS and intracranial angioplasty/stenting. Trial registration number: NCT03370939 .