Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging. Issue 1 (2nd August 2021)

• Record Type: Journal Article
• Authors: Tomar, Ankit Singh; Finger, Paul T; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew; Brennan, Rachel; Burges, Michala; Kim, Jonathan; Berry, Jesse L; Jubran, Rima; Khetan, Vikas; Ganeshan, Suganeswari; Yarovoy, Andrey; Yarovaya, Vera; Kotova, Elena; Volodin, Denis; Yousef, Yacoub; Nummi, Kalle; Ushakova, Tatiana L; Yugay, Olga V; Polyakov, Vladimir G; Ramirez-Ortiz, Marco Antonio; Esparza-Aguiar, Elizabeth; Chantada, Guillermo L; Schaiquevich, Paula; Fandiño, Adriana C; Yam, Jason C; Lau, Winnie W; Lam, Carol P; Sharwood, Phillipa; Moorthy, Sonia; Long, Quah Boon; Essuman, Vera Adobea; Renner, Lorna A; Semenova, Ekaterina; Català-Mora, Jaume; Correa Llano, Maria; Carreras, Elisa;
• Other Names: author non-byline.; Coupland Sarah E author non-byline.; Albert Daniel M author non-byline.; Amiryan Anush G author non-byline.; Saakyan Svetlana author non-byline.; Auw-Hädrich Claudia author non-byline.; Baker Diane author non-byline.; Barnhill Raymond author non-byline.; Caminal José M author non-byline.; Caroll William L author non-byline.; Cassoux Nathalie author non-byline.; Desjardins Laurence G author non-byline.; Doz François author non-byline.; Pierron Gaelle author non-byline.; Chévez-Barrios Patricia author non-byline.; Max Conway R author non-byline.; Damato Bertil E author non-byline.; Demirci Hakan author non-byline.; Dutton Jonathan J author non-byline.; Esmaeli Bita author non-byline.; Prieto Victor G author non-byline.; Williams Michelle author non-byline.; Gallie Brenda L author non-byline.; Graue Gerardo F author non-byline.; Grossniklaus Hans E author non-byline.; Heegaard Steffen author non-byline.; Holbach Leonard M author non-byline.; Honavar Santosh G author non-byline.; Jager Martine J author non-byline.; Kujala Emma author non-byline.; Rouic Livia Lumbroso-Le author non-byline.; Modorati Giulio M author non-byline.; Munier Francis L author non-byline.; Murray Timothy G author non-byline.; Pavlick Anna C author non-byline.; Pe'er Jacob author non-byline.; Pelayes David E author non-byline.; Rodriguez Manuel Jorge author non-byline.; Sauerwein Wolfgang AG author non-byline.; Seregard Stefan author non-byline.; Shields Carol author non-byline.; Rand Simpson E author non-byline.; Singh Arun D author non-byline.; Suzuki Shigenobu author non-byline.; Washington Mary Kay author non-byline.; White Valerie A author non-byline.; Wilson Mathew W author non-byline.; Wittekind Christian W author non-byline.; Yin Vivian author non-byline.;
• Is Part Of: British journal of ophthalmology. Volume 107:Issue 1(2023)
• Page Start: 127
• Page End: 132
• Publication Date: 2021-08-02
• Subjects: pathology -- neoplasia -- retina -- vitreous; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2021-318892
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aim: To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods: Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results: Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion: This international, multicentre, registry-based analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage.