The DisEntangling Chronic Obstructive pulmonary Disease Exacerbations clinical trials NETwork (DECODE-NET): rationale and vision. Issue 1 (2nd July 2020)

• Record Type: Journal Article
• Authors: Mathioudakis, Alexander G.; Sivapalan, Pradeesh; Papi, Alberto; Vestbo, Jørgen
• Other Names: Abroug Fekri author non-byline.; Agusti Alvar author non-byline.; Attaway Amy author non-byline.; Bakke Per author non-byline.; Barjaktarevic Igor author non-byline.; Bartziokas Konstantinos author non-byline.; Beghè Bianca author non-byline.; Bhatt Surya P. author non-byline.; Bikov Andras author non-byline.; Bradbury Thomas author non-byline.; Brusselle Guy author non-byline.; Burkes Robert author non-byline.; Cadus Cordula author non-byline.; Contoli Marco author non-byline.; Corlateanu Alexandru author non-byline.; Corlateanu Olga author non-byline.; Criner Gerard author non-byline.; Csoma Balazs author non-byline.; Dean Victoria author non-byline.; Diaz Philip author non-byline.; Dransfield Mark T. author non-byline.; Echevarria Carlos author non-byline.; Eklöf Josephin author non-byline.; Emelyanov Alexander author non-byline.; Faner Rosa author non-byline.; Fernandez Romero Gustavo author non-byline.; Gaeckle Nate author non-byline.; Hammouda Zeineb author non-byline.; Han MeiLan K. author non-byline.; Hill Nicholas S. author non-byline.; Horvath Peter author non-byline.; Huerta Arturo author non-byline.; Iyer Anand author non-byline.; Jacobs Michael author non-byline.; Jenkins Christine author non-byline.; Jensen Jens-Ulrik author non-byline.; Joos Guy author non-byline.; Kharevich Olga author non-byline.; Kostikas Konstantinos author non-byline.; Krishnan Jerry A. author non-byline.; LaBedz Stephanie author non-byline.; Lafon David author non-byline.; Lapteva Elena author non-byline.; Lazar Zsofia author non-byline.; Leuppi Jörg D. author non-byline.; Liddle Carol author non-byline.; Linnell John author non-byline.; López-Giraldo Alejandra author non-byline.; Martinez Fernando D. author non-byline.; Martinez Fernando J. author non-byline.; Mathioudakis Alexander G. author non-byline.; McDonald Vanessa author non-byline.; Mkorombindo Takudzwa author non-byline.; Moy Marilyn author non-byline.; Nielsen Rune author non-byline.; Papi Alberto author non-byline.; Panos Ralph author non-byline.; Parekh Trisha author non-byline.; Pavord Ian author non-byline.; Pinto-Plata Victor author non-byline.; Reed Robert M. author non-byline.; Rommes Jean author non-byline.; Saraiva Isabel author non-byline.; Sergeeva Galina author non-byline.; Sciurba Frank C. author non-byline.; Singh Dave author non-byline.; Sivapalan Pradeesh author non-byline.; Stolz Daiana author non-byline.; Strange Charlie author non-byline.; Wang Hao author non-byline.; Wen Fuqiang author non-byline.; Vestbo Jørgen author non-byline.; Wells James M. author non-byline.; Williamson Paula R. author non-byline.; Yorke Janelle author non-byline.;
• Is Part Of: European respiratory journal. Volume 56:Issue 1(2020)
• Publication Date: 2020-07-02
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00627-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

Acute exacerbations are largely responsible for the poor outcomes characterising COPD, the third leading cause of death globally and associated with a significant disability and socioeconomic burden [1, 2]. Every year, 22–40% of all people suffering from COPD experience at least one moderate or severe exacerbation, while 9–16% experience more than one [3, 4]. Exacerbations are associated with an increased risk of subsequent exacerbations, cardiac events, worse quality of life and an accelerated lung function decline [5]. 15% of all severe exacerbations requiring hospitalisation lead to death within 90 days [6]. Thus, it is not surprising that patients consider exacerbations and hospitalisations due to exacerbations the most important, burdensome outcomes of COPD [7]. The DisEntangling Chronic Obstructive pulmonary Disease Exacerbations clinical trials NETwork: #DECODE_NET. Vision statement of an emerging, global network aiming to conduct collaborative clinical research on COPD exacerbation management @ERSpublications https://bit.ly/36kISgp