Prevalence and recovery of adrenal insufficiency in steroid-dependent asthma patients receiving biologic therapy. Issue 1 (30th July 2020)

• Record Type: Journal Article
• Authors: Nanzer, Alexandra M.; Chowdhury, Aqib; Raheem, Asma; Roxas, Cris; Fernandes, Mariana; Thomson, Louise; Green, Linda; Dhariwal, Jaideep; D'Ancona, Grainne; Kent, Brian D.; Kelly, Philip A.; Jackson, David J.
• Is Part Of: European respiratory journal. Volume 56:Issue 1(2020)
• Publication Date: 2020-07-30
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02273-2019
• Languages: English
• ISSNs: 0903-1936

Abstract

Asthma is a complex and heterogeneous inflammatory disease of the airways. Regular inhaled corticosteroid (ICS) therapy suppresses airway inflammation and treats asthma symptoms sufficiently in most patients. However, a small, but significant, proportion of patients with severe disease suffer from persistent daily symptoms and are reliant on oral corticosteroids (OCS), for short-term control in acute exacerbations, or as long-term maintenance therapy [1]. Adrenal insufficiency is common in previously steroid-dependent asthma patients. Morning serum cortisol is a valid and important first line test which can indicate adrenal insufficiency and can guide who might need dynamic testing. http://bit.ly/2IVGNfI