Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients. Issue 2 (27th August 2020)

• Record Type: Journal Article
• Authors: Yu, Hai-qiong; Sun, Bao-qing; Fang, Zhang-fu; Zhao, Jin-cun; Liu, Xiao-yu; Li, Yi-min; Sun, Xi-zhuo; Liang, Hong-feng; Zhong, Bei; Huang, Zhi-feng; Zheng, Pei-yan; Tian, Li-feng; Qu, Hui-Qi; Liu, De-chen; Wang, Er-yi; Xiao, Xiao-jun; Li, Shi-yue; Ye, Feng; Guan, Li; Hu, Dong-sheng; Hakonarson, Hakon; Liu, Zhi-gang; Zhong, Nan-shan
• Is Part Of: European respiratory journal. Volume 56:Issue 2(2020)
• Publication Date: 2020-08-27
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01526-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

In comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 appears to be more contagious [1], and coronavirus disease 2019 (COVID-19) patients demonstrate varied clinical manifestations distinct from those seen in patients with SARS-CoV and Middle East respiratory syndrome coronavirus infections [2]. Collective results from the clinical and epidemiological observations suggest a distinct viral–host interaction in COVID-19 patients. Profiling of the antibody response during SARS-CoV-2 infection may help improve our understanding of the viral–host interaction and the immunopathological mechanisms of the disease. Humoral immune response to SARS-CoV-2 showed an early response of IgA, instead of IgM, in COVID-19 patients. As highlighted by this study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19. https://bit.ly/3fA7c1I