Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease. Issue 5 (19th November 2020)

• Record Type: Journal Article
• Authors: Jorge, Carmen; Targa, Adriano; Benítez, Iván David; Dakterzada, Faride; Torres, Gerard; Minguez, Olga; Carnes, Anna; Pujol, Montse; Gibert, Aurora; López, Ricard; Gaeta, Anna Michela; Dalmases, Mireia; Farré, Ramón; Sánchez-de-la-Torre, Manuel; Barbé, Ferran; Piñol-Ripoll, Gerard
• Is Part Of: European respiratory journal. Volume 56:Issue 5(2020)
• Publication Date: 2020-11-19
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00523-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

We evaluated the influence of untreated obstructive sleep apnoea (OSA) on the magnitude of cognitive decline and on several cognitive subdomains in patients with mild-to-moderate Alzheimer's disease. In this single-centre study, 144 patients were recruited prospectively from a cognitive impairment unit and underwent overnight polysomnography. The mean±sd change in the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) score at 12 months was 3.19±5.61 in the non-OSA group and 0.08±5.62 in the OSA group, with an intergroup difference of −3.36 (95% CI 0.19–0.16; p=0.002). We did not observe a significant difference in any cognitive subdomains at 12 months. Regarding Mini-Mental State Examination scores at 36 months, the mean change was 1.69 (95% CI −1.26–4.64; p=0.445). No significant differences were found among different OSA severity groups. We observed that ADAS-cog scores were better in the OSA group than in the non-OSA group by a statistically but not clinically significant margin. We did not find differences in the different cognitive subdomains after 1 year or in global cognition after 3 years of follow-up. Untreated OSA did not decrease the cognitive evolution of a population with mild and moderate Alzheimer's disease https://bit.ly/3e55zYH