Altered pulmonary capillary blood volume in childhood sickle cell disease. Issue 6 (10th December 2020)

• Record Type: Journal Article
• Authors: Bokov, Plamen; Boizeau, Priscilla; Pautrat, Jade; Missud, Florence; Ba, Aissatou; Haouari, Zinédine; Denjean, André; Delclaux, Christophe; Benkerrou, Malika
• Is Part Of: European respiratory journal. Volume 56:Issue 6(2020)
• Publication Date: 2020-12-10
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00379-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudry et al. [3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history. Children with sickle cell disease have a pulmonary capillary blood volume that is already dilated at rest and that may initiate a restrictive defect https://bit.ly/2MRaqkc