Bronchial thermoplasty in patients with dynamic hyperinflation: results from the proof-of-concept HEAT trial. Issue 1 (28th January 2021)

• Record Type: Journal Article
• Authors: Guibert, Nicolas; Guilleminault, Laurent; Lepage, Benoit; Heluain, Valentin; Fumat, Romane; Dupuis, Marion; Faviez, Guillaume; Plat, Gavin; Hermant, Christophe; Didier, Alain
• Is Part Of: European respiratory journal. Volume 57:Issue 1(2021)
• Publication Date: 2021-01-28
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01616-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

Severe refractory asthma affects 3–5% of asthmatic patients, but represents 50–80% of asthma-related healthcare costs [1]. Although therapies targeting IgE and, more recently, IL5 and IL4/13 have recently gained approval for the treatment of severe refractory asthma in a subset of patients with type 2 phenotypes, there is still a need to cover a wider range of patients, in particular those with a non-type 2 phenotype or for whom biotherapies failed. Bronchial thermoplasty improves severe asthma with dynamic hyperinflation. The presence of dynamic hyperinflation is a potential marker for bronchial thermoplasty efficacy in severe refractory asthma. https://bit.ly/2POltMC