Honing in on the effectors of oxidative stress in the asthmatic lung: oxidised phosphatidylcholines. Issue 2 (18th February 2021)

• Record Type: Journal Article
• Authors: Penn, Raymond B.
• Is Part Of: European respiratory journal. Volume 57:Issue 2(2021)
• Publication Date: 2021-02-18
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.03736-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

Oxidative stress is a major pathogenic driver in many diseases, and evidence to date suggests the obstructive lung disease asthma is no exception. Various lung insults, including air pollution, smoking and allergens can induce reactive oxygen species (ROS) in the lung [1]. Pascoe et al . examine BAL samples from asthmatic patients challenged with diluent or allergen, and from patients with/without AHR, to establish the specific oxidised PCs that associate with AHR and are induced by allergic lung challenge. https://bit.ly/2TeSzH6