Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals. Issue 3 (18th March 2021)

• Record Type: Journal Article
• Authors: Rocha, Vânia; Fraga, Sílvia; Moreira, Carla; Carmeli, Cristian; Lenoir, Alexandra; Steptoe, Andrew; Giles, Graham; Goldberg, Marcel; Zins, Marie; Kivimäki, Mika; Vineis, Paolo; Vollenweider, Peter; Barros, Henrique; Stringhini, Silvia
• Other Names: author non-byline.; Alberts Jan author non-byline.; Alenius Harri author non-byline.; Avendano Mauricio author non-byline.; Baglietto Laura author non-byline.; Baltar Valeria author non-byline.; Barros Henrique author non-byline.; Bartley Mel author non-byline.; Bellone Michele author non-byline.; Berger Eloise author non-byline.; Blane David author non-byline.; Bochud Murielle author non-byline.; Candiani Giulia author non-byline.; Carmeli Cristian author non-byline.; Carra Luca author non-byline.; Castagne Raphaele author non-byline.; Chadeau-Hyam Marc author non-byline.; Cima Sergio author non-byline.; Costa Giuseppe author non-byline.; Courtin Emilie author non-byline.; Delpierre Cyrille author non-byline.; D'Errico Angelo author non-byline.; Donkin Angela author non-byline.; Dugue Pierre-Antoine author non-byline.; Elliott Paul author non-byline.; Fagherazzi Guy author non-byline.; Fiorito Giovanni author non-byline.; Fraga Silvia author non-byline.; Gandini Martina author non-byline.; Gares Valérie author non-byline.; Gerbouin-Rerolle Pascale author non-byline.; Giles Graham author non-byline.; Goldberg Marcel author non-byline.; Greco Dario author non-byline.; Hodge Allison author non-byline.; Karimi Maryam author non-byline.; Karisola Piia author non-byline.; Kelly-Irving Michelle author non-byline.; Kivimaki Mika author non-byline.; Laine Jessica author non-byline.; Lang Thierry author non-byline.; Laurent Audrey author non-byline.; Layte Richard author non-byline.; Lepage Benoit author non-byline.; Lorsch Dori author non-byline.; Machell Giles author non-byline.; Mackenbach Johan author non-byline.; Marmot Michael author non-byline.; McCrory Cathal author non-byline.; de Mestral Carlos author non-byline.; Miller Cynthia author non-byline.; Milne Roger author non-byline.; Muennig Peter author non-byline.; Nusselder Wilma author non-byline.; Petrovic Dusan author non-byline.; Pilapil Lourdes author non-byline.; Polidoro Silvia author non-byline.; Preisig Martin author non-byline.; Ribeiro Ana Isabel author non-byline.; Ricceri Fulvio author non-byline.; Recalcati Paolo author non-byline.; Reinhard Erica author non-byline.; Robinson Oliver author non-byline.; Valverde Jose Rubio author non-byline.; Saba Severine author non-byline.; Santegoets Frank author non-byline.; Severi Gianluca author non-byline.; Simmons Terrence author non-byline.; Stringhini Silvia author non-byline.; Tabak Adam author non-byline.; Terhi Vesa author non-byline.; Tieulent Joannie author non-byline.; Vaccarella Salvatore author non-byline.; Vigna-Taglianti Federica author non-byline.; Vineis Paolo author non-byline.; Vollenweider Peter author non-byline.; Zins Marie author non-byline.;
• Is Part Of: European respiratory journal. Volume 57:Issue 3(2021)
• Publication Date: 2021-03-18
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.01600-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

Background: Lung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to disadvantaged socioeconomic conditions across the life-course. Methods: This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung function assessed by forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC). 70 496 participants (51% female) aged 18–93 years were included. Socioeconomic disadvantage was measured in early life (low paternal occupational position), early adulthood (low educational level) and adulthood (low occupational position). Risk factors for poor lung function ( e.g. smoking, obesity, sedentary behaviour, cardiovascular and respiratory diseases) were included as potential mediators. The years of lung function lost due to socioeconomic disadvantage were computed at each life stage. Results: Socioeconomic disadvantage during the life-course was associated with a lower FEV1 . By the age of 45 years, individuals experiencing disadvantaged socioeconomic conditions had lost 4–5 years of healthy lung function versus their more advantaged counterparts (low educational level −4.36 (95% CI −7.33–−2.37) for males and −5.14 (−10.32–−2.71) for females; low occupational position −5.62 (−7.98–−4.90) for males and −4.32 (−13.31–−2.27) for females), after accounting for the risk factors for lung function. By the ages of 65 years and 85 years, the years of lung function lost due to socioeconomic disadvantage decreased by 2–4 years, depending on the socioeconomic indicator. Sensitivity analysis using FVC yielded similar results to those using FEV1 . Conclusion: Life-course socioeconomic disadvantage is associated with lower lung function and predicts a significant number of years of lung function loss in adulthood and at older ages. This multicohort study of 70 496 individuals from four European countries shows that life-course socioeconomic disadvantage is associated with a lower lung function and is an important predictor of years of lung function loss during adulthood and older ages https://bit.ly/3huxpOX