Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). Issue 5 (6th May 2021)

• Record Type: Journal Article
• Authors: Bettiol, Alessandra; Sinico, Renato Alberto; Schiavon, Franco; Monti, Sara; Bozzolo, Enrica Paola; Franceschini, Franco; Govoni, Marcello; Lunardi, Claudio; Guida, Giuseppe; Lopalco, Giuseppe; Paolazzi, Giuseppe; Vacca, Angelo; Gregorini, Gina; Leccese, Pietro; Piga, Matteo; Conti, Fabrizio; Fraticelli, Paolo; Quartuccio, Luca; Alberici, Federico; Salvarani, Carlo; Bettio, Silvano; Negrini, Simone; Selmi, Carlo; Sciascia, Savino; Moroni, Gabriella; Colla, Loredana; Manno, Carlo; Urban, Maria Letizia; Vannacci, Alfredo; Pozzi, Maria Rosa; Fabbrini, Paolo; Polti, Stefano; Felicetti, Mara; Marchi, Maria Rita; Padoan, Roberto; Delvino, Paolo; Caporali, Roberto; Montecucco, Carlomaurizio; Dagna, Lorenzo; Cariddi, Adriana; Toniati, Paola; Tamanini, Silvia; Furini, Federica; Bortoluzzi, Alessandra; Tinazzi, Elisa; Delfino, Lorenzo; Badiu, Iuliana; Rolla, Giovanni; Venerito, Vincenzo; Iannone, Florenzo; Berti, Alvise; Bortolotti, Roberto; Racanelli, Vito; Jeannin, Guido; Padula, Angela; Cauli, Alberto; Priori, Roberta; Gabrielli, Armando; Bond, Milena; Tedesco, Martina; Pazzola, Giulia; Tomietto, Paola; Pellecchio, Marco; Marvisi, Chiara; Maritati, Federica; Palmisano, Alessandra; Dejaco, Christian; Willeit, Johann; Kiechl, Stefan; Olivotto, Iacopo; Willeit, Peter; Prisco, Domenico; Vaglio, Augusto; Emmi, Giacomo;
• Other Names: author non-byline.; Bargagli Elena author non-byline.; Becatti Matteo author non-byline.; Beccalli Mirko author non-byline.; Bello Federica author non-byline.; Bozzao Francesco author non-byline.; Canti Valentina author non-byline.; Cassia Matthias A. author non-byline.; Cassone Giulia author non-byline.; Catanoso Mariagrazia author non-byline.; Chieco-Bianchi Fulvia author non-byline.; Clari Roberta author non-byline.; Coladonato Laura author non-byline.; De Santis Maria author non-byline.; Di Scala Gerardo author non-byline.; Fagni Filippo author non-byline.; Fenaroli Paride author non-byline.; Fiorillo Claudia author non-byline.; Floris Alberto author non-byline.; Fornaro Marco author non-byline.; Galli Elena author non-byline.; Generali Elena author non-byline.; Giliberti Marica author non-byline.; Lascaro Nancy author non-byline.; Leccese Ilaria author non-byline.; Mattioli Irene author non-byline.; Olivieri Bianca author non-byline.; Osti Nicola author non-byline.; Peyronel Francesco author non-byline.; Radin Massimo author non-byline.; Righetti Giulia author non-byline.; Salvati Stefano author non-byline.; Silvestri Elena author non-byline.; Susca Nicola author non-byline.; Tamburini Carlo author non-byline.; Taurisano Giusy author non-byline.; Trezzi Barbara author non-byline.; Trivioli Giorgio author non-byline.;
• Is Part Of: European respiratory journal. Volume 57:Issue 5(2021)
• Publication Date: 2021-05-06
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.04158-2020
• Languages: English
• ISSNs: 0903-1936

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) characterised by respiratory manifestations and systemic organ involvement [1]. Particularly, cardiac manifestations occur in 40–60% of patients, representing the leading cause of mortality [2]. Recent reports suggest that venous thromboembolic events might also represent a consistent burden of disease [3, 4], as already known for the other AAVs [5–7], possibly due to eosinophil-mediated vascular inflammation [5]. Nevertheless, the occurrence of arterial and venous thrombotic events (AVTEs) has never been systematically explored in EGPA. Eosinophilic granulomatosis with polyangiitis is associated with a high risk of acute arterial and venous thromboembolic events (AVTE), particularly around the time of diagnosis and in patients with high disease activity or history of previous AVTE http://bit.ly/3sKnvzQ