Hyperforin: A natural lead compound with multiple pharmacological activities. (February 2023)

• Record Type: Journal Article
• Authors: Li, Xin-Xin; Yan, Yu; Zhang, Jia; Ding, Kang; Xia, Cong-Yuan; Pan, Xue-Ge; Shi, Yan-Jing; Xu, Jie-Kun; He, Jun; Zhang, Wei-Ku
• Is Part Of: Phytochemistry. Volume 206(2023)
• Publication Date: 2023-02
• Subjects: Hypericum perforatum -- Clusiaceae -- Hyperforin -- Detection methods -- Pharmacological activities -- Pharmacokinetics -- Synthesis; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113526
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached increasing attention due to its multiple pharmacological activities. In this review, the information on hyperforin was systematically summarized. Hyperforin is considered to be a lead compound with diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes and others. It can be obtained by extraction and synthesis. Further pharmacological studies and more precise detection methods will help develop a value for hyperforin. In addition, structural modification and pharmaceutical preparation technology will be beneficial to promoting the research progress of hyperforin based innovative drugs. Although these works are full of known and unknown challenges, researchers are still expected to make hyperforin play a greater value. Graphical abstract: Image 1 Highlights: Hyperforin is the main antidepressant active ingredient of St. John's wort. Hyperforin is a leading compound with various biological activities. The research progress of hyperforin is objectively updated and analyzed in this review.