Breast lesions with myoepithelial phenotype. Issue 1 (8th December 2022)

• Record Type: Journal Article
• Authors: Foschini, Maria P.; Nishimura, Rieko; Fabbri, Viscardo Paolo; Varga, Zsuzsanna; Kaya, Handan; Cserni, Gábor
• Other Names: Tse Gary M guestEditor.; Tan Puay Hoon guestEditor.; Rakha Emad A guestEditor.
• Is Part Of: Histopathology. Volume 82:Issue 1(2023)
• Page Start: 53
• Page End: 69
• Publication Date: 2022-12-08
• Subjects: myoepithelial cell -- breast -- epithelial cell -- myoepitheliosis -- myoepithelial cell differentiation; Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.14826
• Languages: English
• ISSNs: 0309-0167

Abstract

Abstract : Myoepithelial cells (MECs) constitute a continuous layer of cells surrounding the breast glands, localised between the epithelial cells (ECs) and the basal membrane. MECs play important roles in normal mammary gland as they produce basal membrane and stimulate secretion. During neoplastic transformation, MECs act as a barrier preventing stromal invasion. MECs themselves can undergo a great variety of changes, ranging from hyperplastic to metaplastic, to neoplastic, and giving rise to a wide spectrum of morphological pictures sometimes difficult to interpret on routine diagnoses. Several benign and malignant breast tumours can present features of MECs differentiation. As these latter tumours are quite infrequent, the purpose of the present study is to offer a review of the morphological spectrum of MECs lesions, with correlations to prognosis. Abstract : Summary of MEC alterations. Classification of myoepithelial lesions in the breast.