Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation‐Cl− cotransporters. Issue 12 (20th September 2022)

• Record Type: Journal Article
• Authors: Garneau, Alexandre P.; Slimani, Samira; Haydock, Ludwig; Nsimba‐Batomene, Thy‐René; Préfontaine, Florence C.M.; Lavoie, Mathilde M.; Tremblay, Laurence E.; Fiola, Marie‐Jeanne; Mac‐Way, Fabrice; Isenring, Paul
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 12(2022)
• Page Start: 4356
• Page End: 4368
• Publication Date: 2022-09-20
• Subjects: bone disorders -- K+‐Cl− cotransporters -- Na+‐Cl− cotransporters -- Na+‐K+‐Cl− cotransporters -- osteoblasts -- osteoclasts; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30879
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Bone turnover diseases are exceptionally prevalent in human and come with a high burden on physical health. While these diseases are associated with a variety of risk factors and causes, they are all characterized by common denominators, that is, abnormalities in the function or number of osteoblasts, osteoclasts, and/or osteocytes. As such, much effort has been deployed in the recent years to understand the signaling mechanisms of bone cell proliferation and differentiation with the objectives of exploiting the intermediates involved as therapeutic preys. Ion transport systems at the external and in the intracellular membranes of osteoblasts and osteoclasts also play an important role in bone turnover by coordinating the movement of Ca 2+, PO4 2−, and H + ions in and out of the osseous matrix. Even if they sustain the terminal steps of osteoformation and osteoresorption, they have been the object of very little attention in the last several years. Members of the cation‐Cl − cotransporter (CCC) family are among the systems at work as they are expressed in bone cells, are known to affect the activity of Ca 2+ ‐, PO4 2− ‐, and H + ‐dependent transport systems and have been linked to bone mass density variation in human. In this review, the roles played by the CCCs in bone remodeling will be discussed in light of recent developments and their potential relevance in the treatment of skeletal disorders. Abstract : Ion transport systems in the membranes of osteoblasts and osteoclasts play a key role in bone remodeling by coordinating the movement of Ca 2+, PO4 2−, and H + ions in and out of the osseous matrix. Based on the evidence available, the cation‐Cl − cotransporters could act as unexpectedly important players in this regard. Here, we explain more specifically why by revisiting the data published on the subject and the mechanisms of mineral flux during bone remodeling.