Recent developments in the treatment of small cell lung cancer. (14th July 2021)

• Record Type: Journal Article
• Authors: Hiddinga, Birgitta I.; Raskin, Jo; Janssens, Annelies; Pauwels, Patrick; Van Meerbeeck, Jan P.
• Is Part Of: European respiratory review. Volume 30:Number 161(2021)
• Publication Date: 2021-07-14
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases; Respiratory organs -- Diseases; Respiratory organs -- Diseases -- Treatment; Electronic journals; Periodical; Periodicals; Periodicals; 616.2
• DOI: 10.1183/16000617.0079-2021
• Languages: English
• ISSNs: 0905-9180

Abstract

Small cell lung cancer (SCLC) comprises about 15% of all lung cancers. It is an aggressive disease, with early metastasis and a poor prognosis. Until recently, SCLC treatment remained relatively unchanged, with chemotherapy remaining the cornerstone of treatment. In this overview we will highlight the recent advances in the field of staging, surgery, radiotherapy and systemic treatment. Nevertheless, the prognosis remains dismal and there is a pressing need for new treatment options. We describe the progress that has been made in systemic treatment by repurposing existing drugs and the addition of targeted treatment. In recent years, immunotherapy entered the clinic with high expectations of its role in the treatment of SCLC. Unravelling of the genomic sequence revealed new possible targets that may act as biomarkers in future treatment of patients with SCLC. Hopefully, in the near future, we will be able to identify patients who may benefit from targeted therapy or immunotherapy to improve prognoses. Advances in radiotherapy, targeted treatment and immunotherapy are limited. Progress in treatment options are needed for the treatment of SCLC. Exome sequencing to identify targetable biomarkers could select patients who would benefit from certain therapies. https://bit.ly/3e7ATJ4