Carbendazim toxicity in different cell lines and mammalian tissues. Issue 12 (5th August 2022)

• Record Type: Journal Article
• Authors: Sharma, Monika; Maheshwari, Nikhil; Khan, Fahim Halim; Mahmood, Riaz
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 36:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-05
• Subjects: carbendazim -- cytotoxicity -- genotoxicity -- multiorgan toxicity -- oxidative stress; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.23194
• Languages: English
• ISSNs: 1095-6670

Abstract

Abstract: The extensive production and use of harmful pesticides in agriculture to improve crop yield has raised concerns about their potential threat to living components of the environment. Pesticides cause serious environmental and health problems both to humans and animals. Carbendazim (CBZ) is a broad spectrum fungicide that is used to control or effectively kill pathogenic microorganisms. CBZ is a significant contaminant found in food, soil and water. It exerts immediate and delayed harmful effects on humans, invertebrates, aquatic animals and soil microbes when used extensively and repeatedly. CBZ is a teratogenic, mutagenic and aneugenic agent that imparts its toxicity by enhancing generation of reactive oxygen species generation. It elevates the oxidation of thiols, proteins and lipids and decreases the activities of antioxidant enzymes. CBZ is cytotoxic causing hematological abnormalities, mitotic spindle deformity, inhibits mitosis and alters cell cycle events which lead to apoptosis. CBZ is known to cause endocrine‐disruption, embryo toxicity, infertility, hepatic dysfunction and has been reported to be one of the leading causes of neurodegenerative disorders. CBZ is dangerous to human health, the most common side effects upon chronic exposure are thyroid gland dysfunction and oxidative hepato‐nephrotoxicity. In mammals, CBZ has been shown to disrupt the antioxidant defense system. In this review, CBZ‐induced toxicity in different cells, tissues and organisms, under in vitro and in vivo conditions, has been systematically discussed. Highlights: Carbendazim (CBZ) is a broad spectrum fungicide that is utilized worldwide Humans are readily exposed to CBZ followed by its toxicity CBZ induces oxidative stress leading to apoptosis CBZ is teratogenic, mutagenic, and aneugenic, as well as inhibits mitosis and disrupts cell cycle events CBZ is hemotoxic and causes multiorgan toxicity in various animal models