Association between nut consumption and cancer risk: a meta-analysis. (13th December 2022)

• Record Type: Journal Article
• Authors: Cao, Chang; Gan, Xinyan; He, Yan; Nong, Shiqi; Su, Yonglin; Liu, Zheran; Zhang, Yu; Hu, Xiaolin; Peng, Xingchen
• Is Part Of: Nutrition and cancer. Volume 75:Number 1(2023)
• Page Start: 82
• Page End: 94
• Publication Date: 2022-12-13
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2022.2104880
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: This study aims to conduct a meta-analysis and dose-response analysis of the relationship between nut intake and cancer risk and mortality. Electronic databases were searched. A meta-analysis was conducted to calculate the pooled effect sizes (ESs) with the corresponding 95% CIs, and a dose-response analysis was performed. A random-effects model was used in the statistical analysis. Two independent reviewers completed the full-text screening, data extraction, and quality assessment. We included 17 articles in the present meta-analysis. Total nuts intake was revealed to be significantly associated with reduced cancer risk (ES: 0.9; 95% CI: 0.86–0.95; P < 0.001) and cancer mortality (ES: 0.88; 95% CI: 0.85–0.92, P < 0.001), especially lung cancer risk (ES: 0.86; 95% CI: 0.81–0.91, P < 0.001) and gastric cancer risk (ES: 0.79; 95% CI: 0.68–0.91, P = 0.001). Moreover, a 10 g/d increment of tree nuts consumption was associated with a 20% cancer mortality reduction (ES: 0.80; 95% CI: 0.71–0.89; P < 0.0001). Nuts intake is significantly associated with the reduction of cancer risk and mortality. Especially, nuts intake is significantly associated with reduced lung cancer risk and gastric cancer risk. Noticeably, a 10 g/d increase in tree nuts intake is related to a 20% reduction in overall cancer mortality.