Genetic overlap between idiopathic pulmonary fibrosis and COVID-19. Issue 1 (7th July 2022)

• Record Type: Journal Article
• Authors: Allen, Richard J.; Guillen-Guio, Beatriz; Croot, Emma; Kraven, Luke M.; Moss, Samuel; Stewart, Iain; Jenkins, R. Gisli; Wain, Louise V.
• Is Part Of: European respiratory journal. Volume 60:Issue 1(2022)
• Publication Date: 2022-07-07
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.03132-2021
• Languages: English
• ISSNs: 0903-1936

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease potentially leading to long-lasting respiratory symptoms and has resulted in over 4 million deaths worldwide. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease (ILD) characterised by an aberrant response to alveolar injury leading to progressive scarring of the lungs. Individuals with ILD are at a higher risk of death from COVID-19 [1]. Positive genetic correlations for COVID-19 and IPF point to interferon-mediated innate immunity in both response to infection and chronic disease whilst negatively correlated signals highlight implications for drug targeting https://bit.ly/37MMxZa