Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?. Issue 2 (11th August 2022)

• Record Type: Journal Article
• Authors: Riccardi, Daniela; Ward, Jeremy P.T.; Yarova, Polina L.; Janssen, Luke J.; Lee, Tak Hong; Ying, Sun; Corrigan, Chris J.
• Is Part Of: European respiratory journal. Volume 60:Issue 2(2022)
• Publication Date: 2022-08-11
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.02103-2021
• Languages: English
• ISSNs: 0903-1936

Abstract

In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics. Negative allosteric modulators of the calcium-sensing receptor (calcilytics) delivered topically to the airways have the potential to revolutionise asthma therapy https://bit.ly/3tdSZkC